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Mitochondria tether to Focal Adhesions during cell migration and regulate their size

Redaet Daniel, Abebech Mengeta, Patricia Bilodeau, View ORCID ProfileJonathan M Lee
doi: https://doi.org/10.1101/827998
Redaet Daniel
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Abebech Mengeta
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Patricia Bilodeau
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Jonathan M Lee
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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  • ORCID record for Jonathan M Lee
  • For correspondence: jlee@uottawa.ca
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Abstract

Mitochondria are the key generators of ATP in a cell. Visually, they are highly dynamic organelles that undergo cellular fission and fusion events in response to changing cellular energy requirements. Mitochondria are now emerging as regulators of mammalian cell motility. Here we show that mitochondria infiltrate the leading edge of NIH3T3 fibroblasts during migration. At the leading edge, we find that mitochondria move to and tether to Focal Adhesions (FA). FA regulate cell migration by coupling the cytoskeleton to the Extracellular Matrix through integrin receptors. Importantly, we find that inhibition of mitochondrial ATP generation concomitantly inhibits FA size. This suggests that mitochondrial energy production regulates migration through FA control.

Footnotes

  • Funding: This work was supported by operating funds from the Natural Sciences and Engineering Research Council of Canada (JML).

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 01, 2019.
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Mitochondria tether to Focal Adhesions during cell migration and regulate their size
Redaet Daniel, Abebech Mengeta, Patricia Bilodeau, Jonathan M Lee
bioRxiv 827998; doi: https://doi.org/10.1101/827998
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Mitochondria tether to Focal Adhesions during cell migration and regulate their size
Redaet Daniel, Abebech Mengeta, Patricia Bilodeau, Jonathan M Lee
bioRxiv 827998; doi: https://doi.org/10.1101/827998

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