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The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles

Gleb Zhelezov, Victor Alfred, Natalia A. Bulgakova, Lyubov Chumakova
doi: https://doi.org/10.1101/831024
Gleb Zhelezov
1Maxwell Institute for Mathematical Sciences, School of Mathematics, University of Edinburgh, Edinburgh, UK
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Victor Alfred
2Department of Biomedical Science, The University of Sheffield, Sheffield, UK
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Natalia A. Bulgakova
2Department of Biomedical Science, The University of Sheffield, Sheffield, UK
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Lyubov Chumakova
1Maxwell Institute for Mathematical Sciences, School of Mathematics, University of Edinburgh, Edinburgh, UK
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  • For correspondence: lchumakova@gmail.com
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Abstract

Cells rely on molecular motors moving along an ever-shifting network of polymers (microtubules) for the targeted delivery of cell organelles to biologically-relevant locations. We present a stochastic model for a molecular motor stepping along a bidirectional bundle of microtubules, as well as a tractable analytical model. Using these models, we investigate how the preferred stepping direction of the motor (parallel or antiparallel to the microtubule growth, corresponding to kinesin and dynein motor families) quantitatively and qualitatively affects the cargo delivery. We predict which motor type is responsible for which cargo type, given the experimental distribution of cargo in the cell, and report experimental findings which support this guideline for motor classification.

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Posted November 05, 2019.
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The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles
Gleb Zhelezov, Victor Alfred, Natalia A. Bulgakova, Lyubov Chumakova
bioRxiv 831024; doi: https://doi.org/10.1101/831024
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The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles
Gleb Zhelezov, Victor Alfred, Natalia A. Bulgakova, Lyubov Chumakova
bioRxiv 831024; doi: https://doi.org/10.1101/831024

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