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Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly
Xingjian Xu, Raquel Godoy-Ruiz, Kaylin A. Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen M. Varney, Mary E. Cook, Braden M. Roth, Paul T. Wilder, Thomas Cleveland, Alexander Grishaev, Heather M. Neu, Sarah Michel, Wenbo Yu, Dorothy Beckett, Richard R. Rustandi, Catherine Lancaster, John W. Loughney, Adam Kristopeit, Sianny Christanti, Jessica W. Olson, Alex D. MacKerell, View ORCID ProfileAmedee des Georges, Edwin Pozharski, David J. Weber
doi: https://doi.org/10.1101/833699
Xingjian Xu
1CUNY Advanced Science Research Center, New York, NY, USA
8PhD Program in Biochemistry, The Graduate Center, CUNY, New York, NY, USA
Raquel Godoy-Ruiz
2University of Maryland School of Medicine, Baltimore, MD, USA
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Kaylin A. Adipietro
2University of Maryland School of Medicine, Baltimore, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Christopher Peralta
1CUNY Advanced Science Research Center, New York, NY, USA
Danya Ben-Hail
1CUNY Advanced Science Research Center, New York, NY, USA
Kristen M. Varney
2University of Maryland School of Medicine, Baltimore, MD, USA
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Mary E. Cook
2University of Maryland School of Medicine, Baltimore, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Braden M. Roth
2University of Maryland School of Medicine, Baltimore, MD, USA
Paul T. Wilder
2University of Maryland School of Medicine, Baltimore, MD, USA
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Thomas Cleveland
5National Institute of Standards, Rockville, MD, USA
Alexander Grishaev
5National Institute of Standards, Rockville, MD, USA
Heather M. Neu
4University of Maryland School of Pharmacy, Baltimore, MD, USA
Sarah Michel
4University of Maryland School of Pharmacy, Baltimore, MD, USA
Wenbo Yu
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
4University of Maryland School of Pharmacy, Baltimore, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Dorothy Beckett
6University of Maryland, College Park, MD, USA
Richard R. Rustandi
7Merck & Co., Inc., Kenilworth, NJ, USA
Catherine Lancaster
7Merck & Co., Inc., Kenilworth, NJ, USA
John W. Loughney
7Merck & Co., Inc., Kenilworth, NJ, USA
Adam Kristopeit
7Merck & Co., Inc., Kenilworth, NJ, USA
Sianny Christanti
7Merck & Co., Inc., Kenilworth, NJ, USA
Jessica W. Olson
7Merck & Co., Inc., Kenilworth, NJ, USA
Alex D. MacKerell
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
4University of Maryland School of Pharmacy, Baltimore, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Amedee des Georges
1CUNY Advanced Science Research Center, New York, NY, USA
8PhD Program in Biochemistry, The Graduate Center, CUNY, New York, NY, USA
9PhD Program in Chemistry, The Graduate Center, CUNY, New York, NY, USA
10Department of Chemistry & Biochemistry, City College of New York, New York, NY, USA
Edwin Pozharski
2University of Maryland School of Medicine, Baltimore, MD, USA
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
David J. Weber
2University of Maryland School of Medicine, Baltimore, MD, USA
3Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
11The Center for Biomolecular Therapeutics, Baltimore, MD, USA
Posted November 08, 2019.
Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly
Xingjian Xu, Raquel Godoy-Ruiz, Kaylin A. Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen M. Varney, Mary E. Cook, Braden M. Roth, Paul T. Wilder, Thomas Cleveland, Alexander Grishaev, Heather M. Neu, Sarah Michel, Wenbo Yu, Dorothy Beckett, Richard R. Rustandi, Catherine Lancaster, John W. Loughney, Adam Kristopeit, Sianny Christanti, Jessica W. Olson, Alex D. MacKerell, Amedee des Georges, Edwin Pozharski, David J. Weber
bioRxiv 833699; doi: https://doi.org/10.1101/833699
Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly
Xingjian Xu, Raquel Godoy-Ruiz, Kaylin A. Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen M. Varney, Mary E. Cook, Braden M. Roth, Paul T. Wilder, Thomas Cleveland, Alexander Grishaev, Heather M. Neu, Sarah Michel, Wenbo Yu, Dorothy Beckett, Richard R. Rustandi, Catherine Lancaster, John W. Loughney, Adam Kristopeit, Sianny Christanti, Jessica W. Olson, Alex D. MacKerell, Amedee des Georges, Edwin Pozharski, David J. Weber
bioRxiv 833699; doi: https://doi.org/10.1101/833699
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