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Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level

Qian Lin, Magdalena Helmreich, Friederike Schlumm, Jennifer M. Li, Drew N. Robson, Florian Engert, Alexander Schier, Tobias Nöbauer, Alipasha Vaziri
doi: https://doi.org/10.1101/833889
Qian Lin
1Laboratory of Neurotechnology and Biophysics, The Rockefeller University, New York, NY
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Magdalena Helmreich
2Research Institute of Molecular Pathology, Vienna, Austria
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Friederike Schlumm
2Research Institute of Molecular Pathology, Vienna, Austria
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Jennifer M. Li
3Rowland Institute, Harvard University, Cambridge, MA
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Drew N. Robson
3Rowland Institute, Harvard University, Cambridge, MA
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Florian Engert
4Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA
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Alexander Schier
4Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA
5Biozentrum, University of Basel, Basel, Switzerland
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Tobias Nöbauer
1Laboratory of Neurotechnology and Biophysics, The Rockefeller University, New York, NY
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Alipasha Vaziri
1Laboratory of Neurotechnology and Biophysics, The Rockefeller University, New York, NY
2Research Institute of Molecular Pathology, Vienna, Austria
6The Kavli Neural Systems Institute, The Rockefeller University, New York, NY
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  • For correspondence: vaziri@rockefeller.edu
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SUMMARY

The neuronal basis of goal-directed behavior requires interaction of multiple separated brain regions. How subcortical regions and their interactions with brain-wide activity are involved in action selection is less understood. We have investigated this question by developing an assay based on whole-brain volumetric calcium imaging using light-field microscopy combined with an operant-conditioning task in larval zebrafish. We find global and recurring dynamics of brain states to exhibit pre-motor bifurcations towards mutually exclusive decision outcomes which arises from a spatially distributed network. Within this network the cerebellum shows a particularly strong pre-motor activity, predictive of both the timing and outcome of behavior up to ∼10 seconds before movement initiation. Furthermore, on the single-trial level, decision directions can be inferred from the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the decision time can be quantitatively predicted by the rate of bi-hemispheric population ramping activity. Our results point towards a cognitive role of the cerebellum and its importance in motor planning.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 11, 2019.
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Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level
Qian Lin, Magdalena Helmreich, Friederike Schlumm, Jennifer M. Li, Drew N. Robson, Florian Engert, Alexander Schier, Tobias Nöbauer, Alipasha Vaziri
bioRxiv 833889; doi: https://doi.org/10.1101/833889
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Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level
Qian Lin, Magdalena Helmreich, Friederike Schlumm, Jennifer M. Li, Drew N. Robson, Florian Engert, Alexander Schier, Tobias Nöbauer, Alipasha Vaziri
bioRxiv 833889; doi: https://doi.org/10.1101/833889

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