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Shared anomalies in cortical reading networks in Chinese and French dyslexic children

Xiaoxia Feng, Irene Altarelli, Karla Monzalvo, Guosheng Ding, Franck Ramus, Hua Shu, Stanislas Dehaene, Xiangzhi Meng, Ghislaine Dehaene-Lambertz
doi: https://doi.org/10.1101/834945
Xiaoxia Feng
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
2Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, NeuroSpin Center, Université Paris-Sud, Université ParisSaclay, Gif-sur-Yvette, France
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Irene Altarelli
2Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, NeuroSpin Center, Université Paris-Sud, Université ParisSaclay, Gif-sur-Yvette, France
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Karla Monzalvo
2Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, NeuroSpin Center, Université Paris-Sud, Université ParisSaclay, Gif-sur-Yvette, France
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Guosheng Ding
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
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Franck Ramus
3Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, CNRS, EHESS), Ecole Normale Supérieure, PSL Research University, Paris, France
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Hua Shu
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
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Stanislas Dehaene
2Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, NeuroSpin Center, Université Paris-Sud, Université ParisSaclay, Gif-sur-Yvette, France
4Collège de France, Paris, France
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Xiangzhi Meng
5School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China
6PekingU-PolyU Center for Child Development and Learning, Peking University, Beijing, China
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  • For correspondence: gdehaene@gmail.com mengxzh@pku.edu.cn
Ghislaine Dehaene-Lambertz
2Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, NeuroSpin Center, Université Paris-Sud, Université ParisSaclay, Gif-sur-Yvette, France
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  • For correspondence: gdehaene@gmail.com mengxzh@pku.edu.cn
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Abstract

To determine whether the neural anomalies underlying developmental dyslexia are universal across languages or influenced by the writing system, we tested 10-year-old Chinese and French children, with or without dyslexia, in a cross-cultural fMRI paradigm. We compared their brain responses to words written in their known script, faces and houses while they were asked to detect a rarely presented star. We observed that impaired reading scores were correlated with a decreased activation to words in several key regions of the reading circuit, including left fusiform gyrus, superior temporal gyrus/sulcus, precentral and middle frontal gyrus. In ROIs previously reported as sensitive to dyslexia, we observed main effects of dyslexia common to Chinese and French readers, without interaction with the children’s native language, suggesting a cross-cultural invariance in the neural anomalies underlying dyslexia. Multivariate pattern analyses further confirmed that dyslexics exhibit a reduced activation to written words in the left fusiform gyrus and left posterior superior temporal gyrus, and not merely a greater inter-individual variability. The impairments in these regions may reflect the causes as well as the consequences of orthographic and phonological deficits in dyslexia in different languages. The current study highlights the existence of common brain mechanisms for dyslexia even in highly different writing systems.

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Posted November 08, 2019.
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Shared anomalies in cortical reading networks in Chinese and French dyslexic children
Xiaoxia Feng, Irene Altarelli, Karla Monzalvo, Guosheng Ding, Franck Ramus, Hua Shu, Stanislas Dehaene, Xiangzhi Meng, Ghislaine Dehaene-Lambertz
bioRxiv 834945; doi: https://doi.org/10.1101/834945
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Shared anomalies in cortical reading networks in Chinese and French dyslexic children
Xiaoxia Feng, Irene Altarelli, Karla Monzalvo, Guosheng Ding, Franck Ramus, Hua Shu, Stanislas Dehaene, Xiangzhi Meng, Ghislaine Dehaene-Lambertz
bioRxiv 834945; doi: https://doi.org/10.1101/834945

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