Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences

K. Shaw, L. Bell, K. Boyd, D.M. Grijseels, D. Clarke, O. Bonnar, H.S. Crombag, C.N. Hall
doi: https://doi.org/10.1101/835728
K. Shaw
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Bell
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Boyd
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.M. Grijseels
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Clarke
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O. Bonnar
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.S. Crombag
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.N. Hall
School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: catherine.hall@sussex.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer’s disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature could explain its sensitivity to damage during neurological conditions, including Alzheimer’s disease, where the brain’s energy supply is decreased.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted November 08, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences
K. Shaw, L. Bell, K. Boyd, D.M. Grijseels, D. Clarke, O. Bonnar, H.S. Crombag, C.N. Hall
bioRxiv 835728; doi: https://doi.org/10.1101/835728
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences
K. Shaw, L. Bell, K. Boyd, D.M. Grijseels, D. Clarke, O. Bonnar, H.S. Crombag, C.N. Hall
bioRxiv 835728; doi: https://doi.org/10.1101/835728

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1647)
  • Biochemistry (2738)
  • Bioengineering (1907)
  • Bioinformatics (10243)
  • Biophysics (4183)
  • Cancer Biology (3218)
  • Cell Biology (4538)
  • Clinical Trials (135)
  • Developmental Biology (2840)
  • Ecology (4460)
  • Epidemiology (2041)
  • Evolutionary Biology (7231)
  • Genetics (5476)
  • Genomics (6813)
  • Immunology (2388)
  • Microbiology (7483)
  • Molecular Biology (2992)
  • Neuroscience (18584)
  • Paleontology (136)
  • Pathology (472)
  • Pharmacology and Toxicology (780)
  • Physiology (1149)
  • Plant Biology (2706)
  • Scientific Communication and Education (680)
  • Synthetic Biology (888)
  • Systems Biology (2846)
  • Zoology (468)