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Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp Richter, Marsha Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson Ryan, Joanna Selfe, Janet Shipley, Siddhartha Kar, Paul Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel Ebner, Meghana Pagadala, Sarah P. Blagden, Tim Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, View ORCID ProfileHannah Carter, Gareth Bond
doi: https://doi.org/10.1101/835918
Ping Zhang
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Isaac Kitchen-Smith
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Lingyun Xiong
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Giovanni Stracquadanio
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
16Institute of Quantitative Biology, Biochemistry, and Biotechnology, SynthSys, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3BF, UK
Katherine Brown
2Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
17Division of Virology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK
Philipp Richter
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Marsha Wallace
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Elisabeth Bond
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Natasha Sahgal
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Samantha Moore
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Svanhild Nornes
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Sarah De Val
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Mirvat Surakhy
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
David Sims
2Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
Xuting Wang
3Environmental Epigenomics and Disease Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences-National Institutes of Health, Research Triangle Park, NC 27709, USA
Douglas A. Bell
3Environmental Epigenomics and Disease Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences-National Institutes of Health, Research Triangle Park, NC 27709, USA
Jorge Zeron-Medina
4Vall d’Hebron University Hospital, Oncology Department, Passeig de la Vall D’Hebron 119, 08035 Barcelona, Spain
Yanyan Jiang
5CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Anderson Ryan
5CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Joanna Selfe
6Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Janet Shipley
6Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Siddhartha Kar
7Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Paul Pharoah
7Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Chey Loveday
8Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW3 6JB, UK
Rick Jansen
9Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, the Netherlands
Lukasz F. Grochola
10Institute for Surgical Pathology, University Hospital of Zurich, Switzerland
Claire Palles
11Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK
Andrew Protheroe
13Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, United Kingdom
Val Millar
14Target Discovery Institute, University of Oxford, Nuffield Department of Medicine, Oxford OX3 7FZ, UK
Daniel Ebner
14Target Discovery Institute, University of Oxford, Nuffield Department of Medicine, Oxford OX3 7FZ, UK
Meghana Pagadala
15Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Sarah P. Blagden
12Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK
Tim Maughan
12Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK
Enric Domingo
12Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK
Ian Tomlinson
11Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK
Clare Turnbull
8Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW3 6JB, UK
Hannah Carter
15Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Gareth Bond
1Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted November 09, 2019.
Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp Richter, Marsha Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson Ryan, Joanna Selfe, Janet Shipley, Siddhartha Kar, Paul Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel Ebner, Meghana Pagadala, Sarah P. Blagden, Tim Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth Bond
bioRxiv 835918; doi: https://doi.org/10.1101/835918
Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp Richter, Marsha Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson Ryan, Joanna Selfe, Janet Shipley, Siddhartha Kar, Paul Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel Ebner, Meghana Pagadala, Sarah P. Blagden, Tim Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth Bond
bioRxiv 835918; doi: https://doi.org/10.1101/835918
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