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Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease
View ORCID ProfileSebastian Werneburg, View ORCID ProfileJonathan Jung, Rejani B. Kunjamma, Seung-Kwon Ha, Nicholas J. Luciano, Cory M. Willis, Guangping Gao, Stephen J. Crocker, Brian Popko, Daniel S. Reich, View ORCID ProfileDorothy P. Schafer
doi: https://doi.org/10.1101/841601
Sebastian Werneburg
1Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Jonathan Jung
1Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Rejani B. Kunjamma
2Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
Seung-Kwon Ha
3Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Nicholas J. Luciano
3Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Cory M. Willis
4Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06032, USA
Guangping Gao
5Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
6Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA 01605, USA
7Department of Microbiologic and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA
Stephen J. Crocker
4Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06032, USA
Brian Popko
2Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
Daniel S. Reich
3Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Dorothy P. Schafer
1Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Article usage
Posted November 15, 2019.
Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, Seung-Kwon Ha, Nicholas J. Luciano, Cory M. Willis, Guangping Gao, Stephen J. Crocker, Brian Popko, Daniel S. Reich, Dorothy P. Schafer
bioRxiv 841601; doi: https://doi.org/10.1101/841601
Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, Seung-Kwon Ha, Nicholas J. Luciano, Cory M. Willis, Guangping Gao, Stephen J. Crocker, Brian Popko, Daniel S. Reich, Dorothy P. Schafer
bioRxiv 841601; doi: https://doi.org/10.1101/841601
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