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Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer
Shunfei Yan, Piyush B. Madhamshettiwar, View ORCID ProfileKaylene J. Simpson, View ORCID ProfileSarah Ellis, View ORCID ProfileJian Kang, View ORCID ProfileCarleen Cullinane, View ORCID ProfileKaren E. Sheppard, View ORCID ProfileKatherine M. Hannan, View ORCID ProfileRoss D. Hannan, View ORCID ProfileElaine Sanij, View ORCID ProfileRichard B. Pearson, View ORCID ProfileKeefe T. Chan
doi: https://doi.org/10.1101/849307
Shunfei Yan
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
Piyush B. Madhamshettiwar
2Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, Australia
Kaylene J. Simpson
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
2Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, Australia
Sarah Ellis
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
Jian Kang
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
Carleen Cullinane
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
Karen E. Sheppard
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
4Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
Katherine M. Hannan
4Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
5John Curtin School of Medical Research, Australian National University, Canberra, Australia
Ross D. Hannan
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
4Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
5John Curtin School of Medical Research, Australian National University, Canberra, Australia
6School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
7Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Elaine Sanij
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
8Department of Pathology, University of Melbourne, Melbourne, Australia
Richard B. Pearson
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
4Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
7Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Keefe T. Chan
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
3Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia
Posted November 20, 2019.
Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer
Shunfei Yan, Piyush B. Madhamshettiwar, Kaylene J. Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E. Sheppard, Katherine M. Hannan, Ross D. Hannan, Elaine Sanij, Richard B. Pearson, Keefe T. Chan
bioRxiv 849307; doi: https://doi.org/10.1101/849307
Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer
Shunfei Yan, Piyush B. Madhamshettiwar, Kaylene J. Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E. Sheppard, Katherine M. Hannan, Ross D. Hannan, Elaine Sanij, Richard B. Pearson, Keefe T. Chan
bioRxiv 849307; doi: https://doi.org/10.1101/849307
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