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Changing environments reveal innovative genetic variation in children’s cortisol responses

View ORCID ProfileLaurel Raffington, View ORCID ProfileMargherita Malanchini, Andrew D. Grotzinger, View ORCID ProfileJames W. Madole, Laura E. Engelhardt, Aditi Sabhlok, Cherry Youn, Megan W. Patterson, View ORCID ProfileK. Paige Harden, Elliot M. Tucker-Drob
doi: https://doi.org/10.1101/856658
Laurel Raffington
1Department of Psychology, University of Texas at Austin, United States
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  • For correspondence: laurel.raffington@austin.utexas.edu
Margherita Malanchini
1Department of Psychology, University of Texas at Austin, United States
2Department of Biological and Experimental Psychology, Queen Mary University of London
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Andrew D. Grotzinger
1Department of Psychology, University of Texas at Austin, United States
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James W. Madole
1Department of Psychology, University of Texas at Austin, United States
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Laura E. Engelhardt
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Aditi Sabhlok
1Department of Psychology, University of Texas at Austin, United States
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Cherry Youn
1Department of Psychology, University of Texas at Austin, United States
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Megan W. Patterson
1Department of Psychology, University of Texas at Austin, United States
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K. Paige Harden
1Department of Psychology, University of Texas at Austin, United States
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Elliot M. Tucker-Drob
1Department of Psychology, University of Texas at Austin, United States
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Abstract

Genetic associations with biopsychosocial phenotypes are often interpreted as evidence that the genome codes for fixed end-states. Instead, a given genotype might regulate a dynamic range of phenotypes in response to environmental change. We collected hair cortisol (n = 1,104), salivary cortisol in reaction to an in-laboratory stressor (n = 537), and diurnal salivary cortisol (n = 488) from twins aged 8-15 years in the Texas Twin Project. Baseline genetic variation in both salivary and hair cortisol was not simply magnified after stressor exposure or after waking. Rather, novel genetic influences on cortisol arose over time. Thus, environmental change can reveal genetic variation that would not otherwise be observed in static cortisol levels. These findings are in line with the notion that the genome regulates individuals’ reactions to the environment that differ across environments.

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Posted November 30, 2019.
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Changing environments reveal innovative genetic variation in children’s cortisol responses
Laurel Raffington, Margherita Malanchini, Andrew D. Grotzinger, James W. Madole, Laura E. Engelhardt, Aditi Sabhlok, Cherry Youn, Megan W. Patterson, K. Paige Harden, Elliot M. Tucker-Drob
bioRxiv 856658; doi: https://doi.org/10.1101/856658
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Changing environments reveal innovative genetic variation in children’s cortisol responses
Laurel Raffington, Margherita Malanchini, Andrew D. Grotzinger, James W. Madole, Laura E. Engelhardt, Aditi Sabhlok, Cherry Youn, Megan W. Patterson, K. Paige Harden, Elliot M. Tucker-Drob
bioRxiv 856658; doi: https://doi.org/10.1101/856658

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