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Secure data storage on DNA hard drives

View ORCID ProfileKaikai Chen, Jinbo Zhu, View ORCID ProfileFilip Boskovic, Ulrich F. Keyser
doi: https://doi.org/10.1101/857748
Kaikai Chen
Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom
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  • ORCID record for Kaikai Chen
Jinbo Zhu
Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom
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Filip Boskovic
Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom
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Ulrich F. Keyser
Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom
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  • For correspondence: ufk20@cam.ac.uk
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Abstract

DNA is emerging as a novel material for digital data storage. The two main challenges are efficient encoding and data security. Here, we develop an approach that allows for writing and erasing data by relying solely on Watson-Crick base pairing of short oligonucleotides to single-stranded DNA overhangs located along a long double-stranded DNA hard drive (DNA-HD). Our enzyme-free system enables fast synthesis-free data writing with predetermined building blocks. The use of DNA base pairing allows for secure encryption on DNA-HDs that requires a physical key and nanopore sensing for decoding. The system is suitable for miniature integration for an end-to-end DNA storage device. Our study opens a novel pathway for rewritable and secure data storage with DNA.

One Sentence Summary Storing digital information on molecules along DNA hard drives for rewritable and secure data storage.

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Posted November 28, 2019.
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Secure data storage on DNA hard drives
Kaikai Chen, Jinbo Zhu, Filip Boskovic, Ulrich F. Keyser
bioRxiv 857748; doi: https://doi.org/10.1101/857748
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Secure data storage on DNA hard drives
Kaikai Chen, Jinbo Zhu, Filip Boskovic, Ulrich F. Keyser
bioRxiv 857748; doi: https://doi.org/10.1101/857748

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