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Multiscale criticality measures as general-purpose gauges of proper brain function

Tomer Fekete, Hermann Hinrichs, Jacobo Diego Sitt, Hans-Jochen Heinze, Oren Shriki
doi: https://doi.org/10.1101/863431
Tomer Fekete
1Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, Israel
2Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Israel
3Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany
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  • For correspondence: tomer.fekete@gmail.com
Hermann Hinrichs
3Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany
4Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
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Jacobo Diego Sitt
5INSERM, U 1127, F-75013 Paris, France
6Institut du Cerveau et de la Moelle Epinière, Hôpital Pitié-Salpêtrière, 47 bd de l’Hôpital, 75013 Paris, France
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Hans-Jochen Heinze
3Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany
4Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
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Oren Shriki
1Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, Israel
2Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Israel
7Department of Computer Science, Ben-Gurion University of the Negev, Israel
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ABSTRACT

The brain is universally regarded as a system for processing information. If so, any behavioral or cognitive dysfunction should lend itself to depiction in terms of information processing deficiencies. Information is characterized by recursive, hierarchical complexity. The brain accommodates this complexity by a hierarchy of large/slow and small/fast spatiotemporal loops of activity. Thus, successful information processing hinges upon tightly regulating the spatiotemporal makeup of activity, to optimally match the underlying multiscale delay structure of such hierarchical networks. Reduced capacity for information processing will then be expressed as deviance from this requisite multiscale character of spatiotemporal activity. This deviance is captured by a general family of multiscale criticality measures (MsCr). We applied MsCr to MEG and EEG data in four telling degraded information processing scenarios: disorders of consciousness, mild cognitive impairment, schizophrenia and preictal activity. Consistently with our previous modeling work, MsCr measures systematically varied with information processing capacity. MsCr measures might thus be able to serve as general gauges of information processing capacity and, therefore, as normative measures of brain health.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 03, 2019.
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Multiscale criticality measures as general-purpose gauges of proper brain function
Tomer Fekete, Hermann Hinrichs, Jacobo Diego Sitt, Hans-Jochen Heinze, Oren Shriki
bioRxiv 863431; doi: https://doi.org/10.1101/863431
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Multiscale criticality measures as general-purpose gauges of proper brain function
Tomer Fekete, Hermann Hinrichs, Jacobo Diego Sitt, Hans-Jochen Heinze, Oren Shriki
bioRxiv 863431; doi: https://doi.org/10.1101/863431

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