New Results
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Zsófia A. Bittner, Xiao Liu, Sabine Dickhöfer, Hubert Kalbacher, Karlotta Bosch, Liudmila Andreeva, Sangeetha Shankar, Ana Tapia-Abellán, Ana Marcu, Stefan Stevanovic, Matthew Mangan, Peter Düwell, Marta Lovotti, Franziska Herster, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Hao Wu, Eicke Latz, View ORCID ProfileAlexander N. R. Weber
doi: https://doi.org/10.1101/864702
Zsófia A. Bittner
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Xiao Liu
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Sabine Dickhöfer
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Hubert Kalbacher
bInterfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany
Karlotta Bosch
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Liudmila Andreeva
cDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, C-213, Boston, MA 02115, USA
dProgram in Cellular and Molecular Medicine, Boston Children’s Hospital, 3 Blackfan Circle, Boston, MA 02115, USA
Sangeetha Shankar
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Ana Tapia-Abellán
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Ana Marcu
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Stefan Stevanovic
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Matthew Mangan
eInstitute of Innate Immunity, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
fGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Peter Düwell
eInstitute of Innate Immunity, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
Marta Lovotti
eInstitute of Innate Immunity, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
Franziska Herster
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Markus W. Löffler
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
gDepartment of General, Visceral and Transplant Surgery, University Hospital Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
hDepartment of Clinical Pharmacology, University Hospital Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany
iiFIT – Cluster of Excellence (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Germany
Olaf-Oliver Wolz
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Nadine A. Schilling
jInstitute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany
Jasmin Kümmerle-Deschner
kDepartment of Pediatrics I, University Hospital Tübingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany
Samuel Wagner
lInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Elfriede-Aulhorn-Str. 6, 72076 Tübingen, Germany
Anita Delor
mCentre of Chronic Immunodeficiency, University Hospital Freiburg, Engesserstr. 4, 79108 Freiburg, Germany
Bodo Grimbacher
mCentre of Chronic Immunodeficiency, University Hospital Freiburg, Engesserstr. 4, 79108 Freiburg, Germany
nInstitute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Germany
oDZIF – German Center for Infection Research, Satellite Center Freiburg, Germany
pCIBSS – Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany
qRESIST – Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Germany
Hao Wu
cDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, C-213, Boston, MA 02115, USA
dProgram in Cellular and Molecular Medicine, Boston Children’s Hospital, 3 Blackfan Circle, Boston, MA 02115, USA
Eicke Latz
eInstitute of Innate Immunity, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
rDivision of Infectious Diseases & Immunology, University of Massachusetts, 364 Plantation St, Worcester, MA 01605, USA
Alexander N. R. Weber
aInterfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
iiFIT – Cluster of Excellence (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Germany
Posted March 20, 2020.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Zsófia A. Bittner, Xiao Liu, Sabine Dickhöfer, Hubert Kalbacher, Karlotta Bosch, Liudmila Andreeva, Sangeetha Shankar, Ana Tapia-Abellán, Ana Marcu, Stefan Stevanovic, Matthew Mangan, Peter Düwell, Marta Lovotti, Franziska Herster, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Hao Wu, Eicke Latz, Alexander N. R. Weber
bioRxiv 864702; doi: https://doi.org/10.1101/864702
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Zsófia A. Bittner, Xiao Liu, Sabine Dickhöfer, Hubert Kalbacher, Karlotta Bosch, Liudmila Andreeva, Sangeetha Shankar, Ana Tapia-Abellán, Ana Marcu, Stefan Stevanovic, Matthew Mangan, Peter Düwell, Marta Lovotti, Franziska Herster, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Hao Wu, Eicke Latz, Alexander N. R. Weber
bioRxiv 864702; doi: https://doi.org/10.1101/864702
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