Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

Marta Maltese, Jeffrey R. March, Alexander G. Bashaw, View ORCID ProfileNicolas X. Tritsch
doi: https://doi.org/10.1101/865006
Marta Maltese
1Neuroscience Institute, New York University School of Medicine, New York, NY 10016, U.S.A., and Fresco Institute for Parkinson’s and Movement Disorders, New York University Langone Health, New York, NY 10016, U.S.A.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey R. March
1Neuroscience Institute, New York University School of Medicine, New York, NY 10016, U.S.A., and Fresco Institute for Parkinson’s and Movement Disorders, New York University Langone Health, New York, NY 10016, U.S.A.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander G. Bashaw
1Neuroscience Institute, New York University School of Medicine, New York, NY 10016, U.S.A., and Fresco Institute for Parkinson’s and Movement Disorders, New York University Langone Health, New York, NY 10016, U.S.A.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicolas X. Tritsch
1Neuroscience Institute, New York University School of Medicine, New York, NY 10016, U.S.A., and Fresco Institute for Parkinson’s and Movement Disorders, New York University Langone Health, New York, NY 10016, U.S.A.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicolas X. Tritsch
  • For correspondence: nicolas.tritsch@nyulangone.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Dopamine (DA) is a critical modulator of brain circuits that control voluntary movements, but our understanding of its influence on the activity of target neurons in vivo remains limited. Here, we use two-photon Ca2+ imaging to monitor the activity of direct and indirect-pathway spiny projection neurons (SPNs) simultaneously in the striatum of behaving mice during acute and prolonged manipulations of DA signaling. We find that increasing and decreasing DA biases striatal activity towards the direct and indirect pathways, respectively, by changing the overall number of SPNs recruited during behavior in a manner not predicted by existing models of DA function. This modulation is drastically altered in a model of Parkinson’s disease. Our results reveal a previously unappreciated population-level influence of DA on striatal output and provide novel insights into the pathophysiology of Parkinson’s disease.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted March 02, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum
Marta Maltese, Jeffrey R. March, Alexander G. Bashaw, Nicolas X. Tritsch
bioRxiv 865006; doi: https://doi.org/10.1101/865006
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum
Marta Maltese, Jeffrey R. March, Alexander G. Bashaw, Nicolas X. Tritsch
bioRxiv 865006; doi: https://doi.org/10.1101/865006

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3505)
  • Biochemistry (7346)
  • Bioengineering (5323)
  • Bioinformatics (20260)
  • Biophysics (10016)
  • Cancer Biology (7743)
  • Cell Biology (11300)
  • Clinical Trials (138)
  • Developmental Biology (6437)
  • Ecology (9951)
  • Epidemiology (2065)
  • Evolutionary Biology (13321)
  • Genetics (9361)
  • Genomics (12583)
  • Immunology (7701)
  • Microbiology (19021)
  • Molecular Biology (7441)
  • Neuroscience (41036)
  • Paleontology (300)
  • Pathology (1229)
  • Pharmacology and Toxicology (2137)
  • Physiology (3160)
  • Plant Biology (6860)
  • Scientific Communication and Education (1272)
  • Synthetic Biology (1896)
  • Systems Biology (5311)
  • Zoology (1089)