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Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons

Paloma P Maldonado, Alvaro Nuno-Perez, Jan Kirchner, Elizabeth Hammock, View ORCID ProfileJulijana Gjorgjieva, Christian Lohmann
doi: https://doi.org/10.1101/866251
Paloma P Maldonado
1Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands
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Alvaro Nuno-Perez
1Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands
2Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, the Netherlands
3Department of Fundamental Neuroscience, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Jan Kirchner
4Max Planck Institute for Brain Research, Frankfurt, Germany
5School of Life Sciences, Technical University of Munich, Freising, Germany
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Elizabeth Hammock
6Program in Neuroscience, The Florida State University, Tallahassee, FL, United States of America
7Department of Psychology, The Florida State University, Tallahassee, FL, United States of America
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Julijana Gjorgjieva
4Max Planck Institute for Brain Research, Frankfurt, Germany
5School of Life Sciences, Technical University of Munich, Freising, Germany
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  • ORCID record for Julijana Gjorgjieva
Christian Lohmann
1Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands
2Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, the Netherlands
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  • For correspondence: c.lohmann@nin.knaw.nl
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Summary

Spontaneous network activity shapes emerging neuronal circuits during early brain development, however how neuromodulation influences this activity is not fully understood. Here, we report that the neuromodulator oxytocin powerfully shapes spontaneous activity patterns. In vivo, oxytocin strongly decreased the frequency and pairwise correlations of spontaneous activity events in visual cortex (V1), but not in somatosensory cortex (S1). This differential effect was a consequence of oxytocin only increasing inhibition in V1 and increasing both inhibition and excitation in S1. The increase in inhibition was mediated by the depolarization and increase in excitability of somatostatin+ (SST) interneurons specifically. Accordingly, silencing SST+ neurons pharmacogenetically fully blocked oxytocin’s effect on inhibition in vitro as well its effect on spontaneous activity patterns in vivo. Thus, oxytocin decreases the excitatory/inhibitory ratio and modulates specific features of V1 spontaneous activity patterns that are crucial for refining developing synaptic connections and sensory processing later in life.

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Posted December 06, 2019.
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Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons
Paloma P Maldonado, Alvaro Nuno-Perez, Jan Kirchner, Elizabeth Hammock, Julijana Gjorgjieva, Christian Lohmann
bioRxiv 866251; doi: https://doi.org/10.1101/866251
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Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons
Paloma P Maldonado, Alvaro Nuno-Perez, Jan Kirchner, Elizabeth Hammock, Julijana Gjorgjieva, Christian Lohmann
bioRxiv 866251; doi: https://doi.org/10.1101/866251

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