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Functional reorganization of brain networks across the human menstrual cycle

Laura Pritschet, Tyler Santander, Evan Layher, Caitlin M. Taylor, Shuying Yu, Michael B. Miller, Scott T. Grafton, Emily G. Jacobs
doi: https://doi.org/10.1101/866913
Laura Pritschet
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
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Tyler Santander
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
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Evan Layher
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
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Caitlin M. Taylor
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
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Shuying Yu
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
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Michael B. Miller
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
2Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA
3Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA
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Scott T. Grafton
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
2Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, CA
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Emily G. Jacobs
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA
3Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA
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  • For correspondence: emily.jacobs@psych.ucsb.edu
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Abstract

The brain is an endocrine organ, sensitive to the rhythmic changes in sex hormone production that occurs in most mammalian species. In rodents and nonhuman primates, estrogen and progesterone’s impact on the brain is evident across a range of spatiotemporal scales. Yet, the influence of sex hormones on the functional architecture of the human brain is largely unknown. In this dense-sampling, deep phenotyping study, we examine the extent to which endogenous fluctuations in sex hormones alter intrinsic brain networks at rest in a woman who underwent brain imaging and venipuncture for 30 consecutive days. Standardized regression analyses illustrate estrogen and progesterone’s widespread influence on cortical dynamics. Time-lagged analyses examined the directionality of these relationships and reveal estrogen’s ability to drive connectivity across major functional brain networks, including the Default Mode and Dorsal Attention Networks, whose hubs are densely populated with estrogen receptors. These results reveal the rhythmic nature in which brain networks reorganize across the human menstrual cycle. Neuroimaging studies that densely sample the individual connectome have begun to transform our understanding of the brain’s functional organization. As these results indicate, taking endocrine factors into account is critical for fully understanding the intrinsic dynamics of the human brain.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 06, 2019.
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Functional reorganization of brain networks across the human menstrual cycle
Laura Pritschet, Tyler Santander, Evan Layher, Caitlin M. Taylor, Shuying Yu, Michael B. Miller, Scott T. Grafton, Emily G. Jacobs
bioRxiv 866913; doi: https://doi.org/10.1101/866913
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Functional reorganization of brain networks across the human menstrual cycle
Laura Pritschet, Tyler Santander, Evan Layher, Caitlin M. Taylor, Shuying Yu, Michael B. Miller, Scott T. Grafton, Emily G. Jacobs
bioRxiv 866913; doi: https://doi.org/10.1101/866913

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