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Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching

View ORCID ProfileZachary L. Fuller, Veronique J.L. Mocellin, View ORCID ProfileLuke Morris, View ORCID ProfileNeal Cantin, Jihanne Shepherd, Luke Sarre, Julie Peng, Yi Liao, Joseph Pickrell, View ORCID ProfilePeter Andolfatto, View ORCID ProfileMikhail Matz, View ORCID ProfileLine K. Bay, View ORCID ProfileMolly Przeworski
doi: https://doi.org/10.1101/867754
Zachary L. Fuller
1Department of Biological Sciences, Columbia University
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  • For correspondence: zlf2101@columbia.edu
Veronique J.L. Mocellin
2Australia Institute of Marine Science
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Luke Morris
2Australia Institute of Marine Science
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Neal Cantin
2Australia Institute of Marine Science
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Jihanne Shepherd
1Department of Biological Sciences, Columbia University
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Luke Sarre
1Department of Biological Sciences, Columbia University
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Julie Peng
3Lewis-Sigler Institute for Integrative Genomics, Princeton University
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Yi Liao
4Department of Integrative Biology, University of Texas at Austin
5Department of Ecology and Evolutionary Biology, University of California, Irvine
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Joseph Pickrell
6Gencove, Inc. New York
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Peter Andolfatto
1Department of Biological Sciences, Columbia University
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Mikhail Matz
4Department of Integrative Biology, University of Texas at Austin
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Line K. Bay
2Australia Institute of Marine Science
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Molly Przeworski
1Department of Biological Sciences, Columbia University
2Australia Institute of Marine Science
3Lewis-Sigler Institute for Integrative Genomics, Princeton University
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Abstract

Although reef-building corals are rapidly declining worldwide, responses to bleaching vary both within and among species. Because these inter-individual differences are partly heritable, they should in principle be predictable from genomic data. Towards that goal, we generated a chromosome-scale genome assembly for the coral Acropora millepora. We then obtained whole genome sequences for 237 phenotyped samples collected at 12 reefs distributed along the Great Barrier Reef, among which we inferred very little population structure. Scanning the genome for evidence of local adaptation, we detected signatures of long-term balancing selection in the heat-shock co-chaperone sacsin. We further used 213 of the samples to conduct a genome-wide association study of visual bleaching score, incorporating the polygenic score derived from it into a predictive model for bleaching in the wild. These results set the stage for the use of genomics-based approaches in conservation strategies.

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  • ↵† co-senior authors

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Posted December 06, 2019.
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Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching
Zachary L. Fuller, Veronique J.L. Mocellin, Luke Morris, Neal Cantin, Jihanne Shepherd, Luke Sarre, Julie Peng, Yi Liao, Joseph Pickrell, Peter Andolfatto, Mikhail Matz, Line K. Bay, Molly Przeworski
bioRxiv 867754; doi: https://doi.org/10.1101/867754
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Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching
Zachary L. Fuller, Veronique J.L. Mocellin, Luke Morris, Neal Cantin, Jihanne Shepherd, Luke Sarre, Julie Peng, Yi Liao, Joseph Pickrell, Peter Andolfatto, Mikhail Matz, Line K. Bay, Molly Przeworski
bioRxiv 867754; doi: https://doi.org/10.1101/867754

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