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Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines

View ORCID ProfileJiajie Jessica Xu, Zuha Yousuf, Zhonghua Ouyang, Eric Kennedy, Patrick A. Lester, View ORCID ProfileTara Martin, View ORCID ProfileTim M. Bruns
doi: https://doi.org/10.1101/868398
Jiajie Jessica Xu
1Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI
2Biointerfaces Institute, University of Michigan, Ann Arbor, MI
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  • ORCID record for Jiajie Jessica Xu
Zuha Yousuf
2Biointerfaces Institute, University of Michigan, Ann Arbor, MI
3Biomedical Engineering Department, University of Michigan, Ann Arbor, MI
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Zhonghua Ouyang
2Biointerfaces Institute, University of Michigan, Ann Arbor, MI
3Biomedical Engineering Department, University of Michigan, Ann Arbor, MI
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Eric Kennedy
2Biointerfaces Institute, University of Michigan, Ann Arbor, MI
3Biomedical Engineering Department, University of Michigan, Ann Arbor, MI
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Patrick A. Lester
1Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI
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Tara Martin
1Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI
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  • ORCID record for Tara Martin
Tim M. Bruns
2Biointerfaces Institute, University of Michigan, Ann Arbor, MI
3Biomedical Engineering Department, University of Michigan, Ann Arbor, MI
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  • For correspondence: bruns@umich.edu
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Abstract

Urodynamic studies, used to understand bladder function, diagnose bladder disease, and develop treatments for dysfunctions, are ideally performed with awake subjects. However, in animal models, especially cats (a common model of spinal cord injury and associated bladder pathology), anesthesia is often required for these procedures and can be a research confounder. This study compared the effects of select agents (dexmedetomidine, alfaxalone, propofol, isoflurane, and α-chloralose) on urodynamic (Δpressure, bladder capacity, bladder compliance, non-voiding contractions, bladder pressure slopes) and anesthetic (change in heart rate [ΔHR], average heart rate [HR], reflexes, induction/recovery times) parameters in repeated cystometrograms across five adult male cats. Δpressure was greatest with propofol, bladder capacity was highest with α-chloralose, non-voiding contractions were greatest with α-chloralose. Propofol and dexmedetomidine had the highest bladder pressure slopes during the initial and final portions of the cystometrograms respectively. Cats progressed to a deeper plane of anesthesia (lower HR, smaller ΔHR, decreased reflexes) under dexmedetomidine, compared to propofol and alfaxalone. Time to induction was shortest with propofol, and time to recovery was shortest with dexmedetomidine. These agent-specific differences in urodynamic and anesthetic parameters in cats will facilitate appropriate study-specific anesthetic choices.

Footnotes

  • Changed title, abstract, and made some minor content edits to align with submission to a specific journal collection.

  • https://osf.io/8zjkp/

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 23, 2019.
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Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines
Jiajie Jessica Xu, Zuha Yousuf, Zhonghua Ouyang, Eric Kennedy, Patrick A. Lester, Tara Martin, Tim M. Bruns
bioRxiv 868398; doi: https://doi.org/10.1101/868398
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Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines
Jiajie Jessica Xu, Zuha Yousuf, Zhonghua Ouyang, Eric Kennedy, Patrick A. Lester, Tara Martin, Tim M. Bruns
bioRxiv 868398; doi: https://doi.org/10.1101/868398

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