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Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action
View ORCID ProfileJames M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, View ORCID ProfileAndrew J. Aguirre, View ORCID ProfileFrancisca Vazquez, View ORCID ProfileAviad Tsherniak
doi: https://doi.org/10.1101/868752
James M. McFarland
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Brenton R. Paolella
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Allison Warren
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Kathryn Geiger-Schuller
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Tsukasa Shibue
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Michael Rothberg
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Olena Kuksenko
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Andrew Jones
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Emily Chambers
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Danielle Dionne
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Samantha Bender
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Brian M. Wolpin
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard Medical School, Boston, MA, USA
4Brigham and Women’s Hospital, Boston, MA, USA
5Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Mahmoud Ghandi
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Itay Tirosh
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Orit Rozenblatt-Rosen
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jennifer A. Roth
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Todd R. Golub
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard Medical School, Boston, MA, USA
7Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
8Howard Hughes Medical Institute, Chevy Chase, MD, USA
Aviv Regev
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
8Howard Hughes Medical Institute, Chevy Chase, MD, USA
9Koch Institute of Integrative Cancer Research, Cambridge, MA, USA
10Department of Biology, MIT, Cambridge, MA, USA
Andrew J. Aguirre
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard Medical School, Boston, MA, USA
4Brigham and Women’s Hospital, Boston, MA, USA
5Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Francisca Vazquez
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Aviad Tsherniak
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
Posted December 08, 2019.
Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak
bioRxiv 868752; doi: https://doi.org/10.1101/868752
Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak
bioRxiv 868752; doi: https://doi.org/10.1101/868752
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