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Phantom auditory perception (tinnitus) is characterised by stronger anticipatory auditory predictions

View ORCID ProfileMarta Partyka, View ORCID ProfileGianpaolo Demarchi, Sebastian Roesch, View ORCID ProfileNina Suess, View ORCID ProfileWilliam Sedley, View ORCID ProfileWinfried Schlee, View ORCID ProfileNathan Weisz
doi: https://doi.org/10.1101/869842
Marta Partyka
1Salzburg Brain Dynamics Lab, Centre of Cognitive Neuroscience, Division of Physiological Psychology, University of Salzburg, Austria
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  • For correspondence: marta.s.partyka@gmail.com
Gianpaolo Demarchi
1Salzburg Brain Dynamics Lab, Centre of Cognitive Neuroscience, Division of Physiological Psychology, University of Salzburg, Austria
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Sebastian Roesch
2Department of Otorhinolaryngology–Head and Neck Surgery, The Paracelsus Private Medical University of Salzburg, Salzburg, Austria
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Nina Suess
1Salzburg Brain Dynamics Lab, Centre of Cognitive Neuroscience, Division of Physiological Psychology, University of Salzburg, Austria
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William Sedley
3Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
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Winfried Schlee
4Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
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Nathan Weisz
1Salzburg Brain Dynamics Lab, Centre of Cognitive Neuroscience, Division of Physiological Psychology, University of Salzburg, Austria
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Abstract

How phantom perceptions arise and the factors that make individuals prone to such experiences are not well understood. An attractive phenomenon to study these questions is tinnitus, a very common auditory phantom perception which is not explained by hyperactivity in the auditory pathway alone. Our framework posits that a predisposition to developing (chronic) tinnitus is dependent on individual traits relating to the formation and utilization of sensory predictions. Predictions of auditory stimulus frequency (remote from tinnitus frequency) were studied using a paradigm parametrically modulating regularity (i.e. predictability) of tone sequences and applying decoding techniques on magnetoencephalographic (MEG) data. For processes likely linked to short-term memory, individuals with tinnitus showed an enhanced anticipatory prediction pattern associated with increasing sequence regularity. In contrast, individuals without tinnitus engaged the same processes following the onset of the to-be-decoded sound. We posit that this tendency to optimally anticipate static and changing auditory inputs may determine which individuals faced with persistent auditory pathway hyperactivity factor it into auditory predictions, and thus perceive it as tinnitus. While our study constitutes a first step relating vulnerability to tinnitus with predictive processing, longitudinal studies are needed to confirm the predisposition model of tinnitus development.

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Posted December 10, 2019.
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Phantom auditory perception (tinnitus) is characterised by stronger anticipatory auditory predictions
Marta Partyka, Gianpaolo Demarchi, Sebastian Roesch, Nina Suess, William Sedley, Winfried Schlee, Nathan Weisz
bioRxiv 869842; doi: https://doi.org/10.1101/869842
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Phantom auditory perception (tinnitus) is characterised by stronger anticipatory auditory predictions
Marta Partyka, Gianpaolo Demarchi, Sebastian Roesch, Nina Suess, William Sedley, Winfried Schlee, Nathan Weisz
bioRxiv 869842; doi: https://doi.org/10.1101/869842

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