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Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, View ORCID ProfileCong Liu
doi: https://doi.org/10.1101/870758
Kun Zhao
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Yaowang Li
3Key Laboratory of Protein Sciences (Tsinghua University), Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China
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Zhenying Liu
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Houfang Long
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Chunyu Zhao
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Feng Luo
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Yunpeng Sun
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Youqi Tao
4Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China
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Xiao-dong Su
5State Key Laboratory of Protein and Plant Gene Research, and Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing 100871, China
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Dan Li
4Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China
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  • For correspondence: liulab@sioc.ac.cn lixueming@tsinghua.edu.cn lidan2017@sjtu.edu.cn
Xueming Li
3Key Laboratory of Protein Sciences (Tsinghua University), Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China
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  • For correspondence: liulab@sioc.ac.cn lixueming@tsinghua.edu.cn lidan2017@sjtu.edu.cn
Cong Liu
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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  • ORCID record for Cong Liu
  • For correspondence: liulab@sioc.ac.cn lixueming@tsinghua.edu.cn lidan2017@sjtu.edu.cn
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Article Information

doi 
https://doi.org/10.1101/870758
History 
  • December 11, 2019.

Article Versions

  • Version 1 (December 10, 2019 - 17:08).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Kun Zhao1,2,#,
  2. Yaowang Li3,#,
  3. Zhenying Liu1,2,
  4. Houfang Long1,2,
  5. Chunyu Zhao1,2,
  6. Feng Luo1,2,
  7. Yunpeng Sun1,2,
  8. Youqi Tao4,
  9. Xiao-dong Su5,
  10. Dan Li4,*,
  11. Xueming Li3,* and
  12. Cong Liu1,2,*
  1. 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
  2. 2University of Chinese Academy of Sciences, Beijing 100049, China
  3. 3Key Laboratory of Protein Sciences (Tsinghua University), Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China
  4. 4Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China
  5. 5State Key Laboratory of Protein and Plant Gene Research, and Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing 100871, China
  1. ↵*To whom correspondence should be addressed. E-mails: liulab{at}sioc.ac.cn (C.L.), lixueming{at}tsinghua.edu.cn (X.L.), lidan2017{at}sjtu.edu.cn (D.L.).
  1. ↵# These authors contributed equally to this work.

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Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure
Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
bioRxiv 870758; doi: https://doi.org/10.1101/870758
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Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure
Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
bioRxiv 870758; doi: https://doi.org/10.1101/870758

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