%PDF-1.6
%
157 0 obj
<>
endobj
116 0 obj
<>stream
2024-03-18T18:37-07:00
2018-06-25T16:15:14-04:00
2024-03-18T18:37-07:00
Acrobat 11.0.19
application/pdf
uuid:6679b05f-beb2-9a4e-be60-450049c53d28
uuid:06f87e90-1dd2-11b2-0a00-1e00e8d6d2ff
Acrobat 11.0.19
endstream
endobj
126 0 obj
<>
endobj
5 0 obj
<>
endobj
135 0 obj
<>
endobj
130 0 obj
<>
endobj
134 0 obj
<>
endobj
115 0 obj
<>stream
2018-06-25T16:14:30-04:00
2018-06-25T16:14:30-04:00
2018-06-25T16:14:30-04:00
Adobe Acrobat 11.0.19
application/pdf
uuid:fa89eec0-5bf6-2149-87f0-2928f81b6698
uuid:4101042b-03e1-764e-9d2f-58aa0a71b841
Adobe Acrobat 11.0.19 Image Conversion Plug-in
endstream
endobj
2 0 obj
<>
endobj
38 0 obj
<>
endobj
55 0 obj
<>
endobj
72 0 obj
<>
endobj
71 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
76 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
77 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
78 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
79 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
80 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
81 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
82 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
181 0 obj
[183 0 R]
endobj
182 0 obj
<>stream
q
360 0 0 197.7599945 0 0 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
8 0 0 8 122.15637 771.99997 Tm
(certified by peer review\) is the author/funder. All rights reserved. No\
reuse allowed without permission. )Tj
30.62596 1 Td
(The copyright holder for this preprint \(which was not)Tj
-15.50899 0 Td
(this version posted June 26, 2018. )Tj
-0.556 0 Td
(; )Tj
0 0 1 rg
-13.56498 0 Td
(https://doi.org/10.1101/355750)Tj
0 g
-1.89 0 Td
(doi: )Tj
-7.22399 0 Td
(bioRxiv preprint )Tj
ET
endstream
endobj
107 0 obj
<>stream
Adobe d # $&& $ %4/ $('++9+'()02520)7;;;;7;;;;;;;;;;;;;;;
$2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@
$2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@
$2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ ^ 8 " "
L# !1AQq"a23BCRr#b$%&5Scst
'()*46789:DEFGHIJTUVWXYZdefghijuvwxyz
q !1AQaq"2R#$34BCr5
b%&'()*6789:DEFGHIJSTUVWXYZcdefghijstuvwxyz ? 0L Ъ0L Ѫ0L Ҫ0L Ӫ0L Ԫ0L ժ0L ֪0L ת0L Ъ0L Ѫ0L Ҫ0L Ӫ0L `0s,%in^F
fmYZ&{xu ؉߱Bщiŭ9\kǠ 3iCm\ZZ#|igw uaڶ?-q5ç+mΓٿUx[RJfvk
P^x7pk[3 ;_\]m7."}7[N O fx|aߕ1ֱ4߿{{ƼRUDg c/rmiOZmdKƕVutѼ ; fWԋVƺk.1Fd} [o '_1iƚN1O@ n7LLZDF"f֞]"8d
3[W15g":fz>0mYLγKMfc 6;#aenMo:LyY
Wדϯ@ D Y}ŽYݧF ?[;[3Qy:g㿄 5xMؘqO{Ln#g.|k֔Ld \Sgq
94idWSsSԝ{{ !<"79{/}]x <W;3Okò:g3o|Of