New Results
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni-Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia-Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo-Riitta Jarvelin, Mika Kähönen, Sharon LR Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda WJH Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott
doi: https://doi.org/10.1101/453332
Evangelos Evangelou
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
He Gao
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
3MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
Congying Chu
4Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, United Kingdom
Georgios Ntritsos
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Paul Blakeley
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
5NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, UK
Andrew R. Butts
6Molecular Medicine; School of Medicine; University of Utah, Salt Lake City, UT
Raha Pazoki
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
Hideaki Suzuki
7Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, Du Cane Raod, London, W12 0NN, UK
8Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo, Aoba, Sendai, 980-8573, Japan
Fotios Koskeridis
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Andrianos M. Yiorkas
9Department of Life Sciences, Brunel University London, London, UK
10Section of Investigative Medicine, Imperial College London, London, UK
Ibrahim Karaman
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
11UK Dementia Research Institute, Imperial College London, London, United Kingdom
Joshua Elliott
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
Stefanie Aeschbacher
12Cardiology Division, University Hospital Basel, 4031 Basel, Switzerland
Traci M. Bartz
13Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
14Department of Biostatistics, University of Washington, Seattle, WA, USA
Sebastian E. Baumeister
15Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
16Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg, 86156 Augsburg, Germany
Peter S. Braund
17Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
18NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
Michael R. Brown
19Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030 USA
Jennifer A. Brody
13Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Toni-Kim Clarke
20Department of Psychiatry, University of Edinburgh, Edinburgh, UK, EH10 5HF
Niki Dimou
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Jessica D. Faul
21Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
Georg Homuth
22Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany
Anne U. Jackson
23Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Katherine A. Kentistou
24Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
25Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland
Peter K. Joshi
24Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Rozenn N. Lemaitre
13Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Penelope A. Lind
26Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
Leo-Pekka Lyytikäinen
27Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland
29Department of Cardiology, Heart Center, Tampere University Hospital, Tampere 33521, Finland
Massimo Mangino
30Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK
31NIHR Biomedical Research Centre at Guys and St Thomas Foundation Trust, London SE1 9RT, UK
Yuri Milaneschi
32Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health research institute, Amsterdam University Medical Center, 1081 HJ Amsterdam, the Netherlands
Christopher P. Nelson
17Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
18NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
Ilja M. Nolte
33Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
Mia-Maria Perälä
34Folkhälsan Research Center, 00290 Helsinki, Finland
35Department of Public Health Solutions, National Institute for Health and Welfare, 00271 Helsinki, Finland
Ozren Polasek
36Faculty of Medicine, University of Split, Split, 21000, Croatia
David Porteous
37Generation Scotland, Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK, EH4 2XU
38Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK, EH8 9JZ
Scott M. Ratliff
39Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Jennifer A. Smith
21Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
39Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Alena Stančáková
40Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland
Alexander Teumer
15Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
41DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany
Samuli Tuominen
42Department of Psychology and Logopedics, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland
Sébastien Thériault
43Population Health Research Institute, McMaster University, L8L 2X2 Hamilton, Canada
44Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, G1V 0A6 Quebec City, Canada
Jagadish Vangipurapu
40Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland
John B. Whitfield
45Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
Alexis Wood
46Department of Pediatrics/Nutrition, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030 USA
Jie Yao
47The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA
Bing Yu
19Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030 USA
Wei Zhao
39Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Dan E. Arking
48McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Juha Auvinen
49Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90220, Oulu, Finland
50Oulunkaari Health Center, 91100 Ii, Finland
Chunyu Liu
51Department of Biostatistics, Boston University School of Public Health
Minna Männikkö
52Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, 90220, Oulu, Finland
Lorenz Risch
53Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, 3010 Bern, Switzerland
54Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein
Jerome I. Rotter
56The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA
Harold Snieder
33Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
Juha Veijola
57Department of Psychiatry, Research Unit of Clinical Neuroscience, 90014 University of Oulu, Finland
59Medical research Center Oulu, University and University Hospital of Oulu, 90220 Oulu, Finland
Alexandra I. Blakemore
9Department of Life Sciences, Brunel University London, London, UK
10Section of Investigative Medicine, Imperial College London, London, UK
Michael Boehnke
23Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Harry Campbell
24Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
David Conen
43Population Health Research Institute, McMaster University, L8L 2X2 Hamilton, Canada
Johan G. Eriksson
60Department of General Practice and Primary health Care, Tukholmankatu 8 B, 00014 University of Helsinki, Finland
62Helsinki University Central Hospital, Unit of General Practice, 00290 Helsinki, Finland
Hans J. Grabe
63Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany
64German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 17475 Greifswald, Germany
Xiuqing Guo
47The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA
Pim van der Harst
65University Medical Center Groningen, University of Groningen, Department of Cardiology, the Netherlands
67Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands
Catharina A. Hartman
68Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
Caroline Hayward
69MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
Andrew C. Heath
70Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA
Marjo-Riitta Jarvelin
71Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, United Kingdom
75Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, United Kingdom
Mika Kähönen
76Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland
77Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Sharon LR Kardia
39Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Michael Kühne
12Cardiology Division, University Hospital Basel, 4031 Basel, Switzerland
Johanna Kuusisto
78Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, and Kuopio University Hospital, 70210 Kuopio, Finland
Markku Laakso
78Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, and Kuopio University Hospital, 70210 Kuopio, Finland
Jari Lahti
42Department of Psychology and Logopedics, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland
Terho Lehtimäki
27Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland
28Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Andrew M. McIntosh
20Department of Psychiatry, University of Edinburgh, Edinburgh, UK, EH10 5HF
38Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK, EH8 9JZ
Karen L. Mohlke
79Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Alanna C. Morrison
19Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030 USA
Nicholas G. Martin
45Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
Albertine J. Oldehinkel
68Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
Brenda WJH Penninx
32Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health research institute, Amsterdam University Medical Center, 1081 HJ Amsterdam, the Netherlands
Bruce M. Psaty
80Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, 98101
81Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101
Olli T. Raitakari
82Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland
83Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20014, Finland
Igor Rudan
24Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Nilesh J. Samani
17Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
18NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
Laura J. Scott
23Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Tim D. Spector
30Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK
Niek Verweij
65University Medical Center Groningen, University of Groningen, Department of Cardiology, the Netherlands
David R. Weir
21Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
James F. Wilson
24Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
69MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
Daniel Levy
84Framingham Heart Study, Framingham, MA, USA
85Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Ioanna Tzoulaki
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
3MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
Jimmy D. Bell
86Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, W1W 6UW
Paul Matthews
7Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, Du Cane Raod, London, W12 0NN, UK
11UK Dementia Research Institute, Imperial College London, London, United Kingdom
Adrian Rothenfluh
6Molecular Medicine; School of Medicine; University of Utah, Salt Lake City, UT
87Departments of Psychiatry, Neurobiology & Anatomy, Human Genetics; School of Medicine; University of Utah, Salt Lake City, UT
Sylvane Desrivières
4Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, United Kingdom
Gunter Schumann
4Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, United Kingdom
Paul Elliott
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK
3MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
11UK Dementia Research Institute, Imperial College London, London, United Kingdom
88National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London, London, UK
89Health Data Research-UK London substantive site, London, UK
Abstract
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted October 30, 2018.
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni-Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia-Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo-Riitta Jarvelin, Mika Kähönen, Sharon LR Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda WJH Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott
bioRxiv 453332; doi: https://doi.org/10.1101/453332
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni-Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia-Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo-Riitta Jarvelin, Mika Kähönen, Sharon LR Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda WJH Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott
bioRxiv 453332; doi: https://doi.org/10.1101/453332
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