Abstract
Summary We developed an efficient tool dedicated to call somatic variants from whole-exome sequencing (WES) data using tumor and its matched normal tissue, plus a user-defined control panel of non-cancer samples. We showed superior performance of LoLoPicker with significantly improved specificity, especially for low-quality cancer samples such as formalin-fixed and paraffinembedded (FFPE) samples.
Implementation and Availability The main scripts are implemented in Python 2.7.8 and the package is released at https://github.com/jcarrotzhang/LoLoPicker.
Copyright
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