Abstract
In a recent publication, Thaweerattanasinp and colleagues employed an in vitro preparation and electrophysiology to investigate firing properties of deep dorsal horn neurons following spinal cord injury during NMDA or zolmitriptan application. Deep dorsal horn neurons were classified into bursting, simple or tonic, with bursting neurons showing NMDA and zolmitriptan sensitivity. Here, we discuss the findings in a methodological framework and propose future experiments of importance for translating the results into a physiological setting.
Footnotes
Single target article citation: Thaweerattanasinp T, Heckman CJ, Tysseling VM. The firing characteristics of deep dorsal horn neurons following acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors. J Neurophysiol, ahead of print, 2016. doi: 10.1152/jn.00198.2016.