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Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population
View ORCID ProfileManuel A. Rivas, Jukka Koskela, Hailiang Huang, Christine Stevens, Brandon E. Avila, Talin Haritunians, Benjamin M. Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P. Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Konrad J. Karczewski, Eric V. Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, NIDDK IBD Genetics consortium, T2D-GENES consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W. Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Matti Pirinen, Aarno Palotie, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Rinse K. Weersma, Andre Franke, Daniel G. MacArthur, Chaim Jalas, Harry Sokol, Ramnik J. Xavier, Ann Pulver, Judy H. Cho, Dermot P.B. McGovern, Mark J. Daly
doi: https://doi.org/10.1101/077180
Manuel A. Rivas
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
2Department of Biomedical Data Science, Stanford, CA, USA
Jukka Koskela
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Hailiang Huang
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Christine Stevens
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Brandon E. Avila
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Talin Haritunians
4F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Benjamin M. Neale
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Mitja Kurki
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Andrea Ganna
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Daniel Graham
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Benjamin Glaser
5Hadassah-Hebrew University Medical Center, Endocrinology and Metabolism Service Department of Internal Medicine, Jerusalem, Israel
Inga Peter
6Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Gil Atzmon
7Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
8Faculty of Natural Sciences, University of Haifa, Haifa, Israel
Nir Barzilai
7Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
Adam P. Levine
9Division of Medicine, University College London, London, UK
Elena Schiff
9Division of Medicine, University College London, London, UK
Nikolas Pontikos
9Division of Medicine, University College London, London, UK
10UCL Genetics Institute, University College London, London, UK
Ben Weisburd
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Konrad J. Karczewski
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Eric V. Minikel
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Britt-Sabina Petersen
11Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
Laurent Beaugerie
12Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris 06, Paris, France
Philippe Seksik
12Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris 06, Paris, France
Jacques Cosnes
12Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris 06, Paris, France
Stefan Schreiber
13Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany
Bernd Bokemeyer
14Gastroenterology Practice, Minden, Germany
Johannes Bethge
13Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany
Graham Heap
15IBD Pharmacogenetics, Royal Devon and Exeter NHS Trust, Exeter, UK
Tariq Ahmad
16Peninsula College of Medicine and Dentistry, Exeter, UK
Vincent Plagnol
10UCL Genetics Institute, University College London, London, UK
Anthony W. Segal
9Division of Medicine, University College London, London, UK
Stephan Targan
4F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Dan Turner
17Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
Paivi Saavalainen
18Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Martti Farkkila
19Department of Medicine, Division of Gastroenterology, Helsinki University Hospital, Helsinki, Finland
Kimmo Kontula
20Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Matti Pirinen
21Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
22Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
Aarno Palotie
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
21Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
23Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Steven R. Brant
24Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
25Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Richard H. Duerr
26Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
27Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Mark S. Silverberg
28Inflammatory Bowel Disease Centre, Mount Sinai Hospital, Toronto, Ontario, Canada
John D. Rioux
29Research Center, Montreal Heart Institute, Montréal, Québec, Canada
30Department of Medicine, Université de Montréal, Montréal, Québec, Canada
Rinse K. Weersma
31Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands
Andre Franke
11Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
Daniel G. MacArthur
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Chaim Jalas
32Bonei Olam, Center for Rare Jewish Genetic Disorders, Brooklyn, NY, USA.
Harry Sokol
12Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris 06, Paris, France
Ramnik J. Xavier
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
33Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Pulver
34Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Judy H. Cho
35Icahn School of Medicine at Mount Sinai, Dr Henry D. Janowitz Division of Gastroenterology, New York, New York, USA
Dermot P.B. McGovern
4F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Mark J. Daly
1Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
3Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Article usage
Posted September 25, 2016.
Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population
Manuel A. Rivas, Jukka Koskela, Hailiang Huang, Christine Stevens, Brandon E. Avila, Talin Haritunians, Benjamin M. Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P. Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Konrad J. Karczewski, Eric V. Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, NIDDK IBD Genetics consortium, T2D-GENES consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W. Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Matti Pirinen, Aarno Palotie, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Rinse K. Weersma, Andre Franke, Daniel G. MacArthur, Chaim Jalas, Harry Sokol, Ramnik J. Xavier, Ann Pulver, Judy H. Cho, Dermot P.B. McGovern, Mark J. Daly
bioRxiv 077180; doi: https://doi.org/10.1101/077180
Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population
Manuel A. Rivas, Jukka Koskela, Hailiang Huang, Christine Stevens, Brandon E. Avila, Talin Haritunians, Benjamin M. Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P. Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Konrad J. Karczewski, Eric V. Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, NIDDK IBD Genetics consortium, T2D-GENES consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W. Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Matti Pirinen, Aarno Palotie, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Rinse K. Weersma, Andre Franke, Daniel G. MacArthur, Chaim Jalas, Harry Sokol, Ramnik J. Xavier, Ann Pulver, Judy H. Cho, Dermot P.B. McGovern, Mark J. Daly
bioRxiv 077180; doi: https://doi.org/10.1101/077180
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