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Multi-omic analysis of urothelial cancer patients treated with PD-L1 blockade demonstrates the contribution of both systemic and somatic factors to the biology of response and resistance
View ORCID ProfileAlexandra Snyder, View ORCID ProfileTavi Nathanson, Samuel Funt, View ORCID ProfileArun Ahuja, View ORCID ProfileJacqueline Buros Novik, Matthew D. Hellmann, View ORCID ProfileEliza Chang, View ORCID ProfileBulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S. Robins, Elaine R. Mardis, Taha Merghoub, View ORCID ProfileJeff Hammerbacher, Jonathan Rosenberg, Dean Bajorin
doi: https://doi.org/10.1101/086843
Alexandra Snyder
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Tavi Nathanson
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Samuel Funt
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Arun Ahuja
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Jacqueline Buros Novik
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Matthew D. Hellmann
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Eliza Chang
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Bulent Arman Aksoy
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Hikmat Al-Ahmadie
3 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065
Erik Yusko
4 Adaptive Biotechnologies, Seattle, WA 98102
Marissa Vignali
4 Adaptive Biotechnologies, Seattle, WA 98102
Sharon Benzeno
4 Adaptive Biotechnologies, Seattle, WA 98102
Mariel Boyd
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Meredith Moran
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Gopa Iyer
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Harlan S. Robins
4 Adaptive Biotechnologies, Seattle, WA 98102
5 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
Elaine R. Mardis
6 Institute for Genomic Medicine; The Research Institute at Nationwide Children's Hospital; The Ohio State University College of Medicine; Columbus, OH 43205
Taha Merghoub
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Jeff Hammerbacher
2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Jonathan Rosenberg
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Dean Bajorin
1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY 10065
Article usage
Posted November 10, 2016.
Multi-omic analysis of urothelial cancer patients treated with PD-L1 blockade demonstrates the contribution of both systemic and somatic factors to the biology of response and resistance
Alexandra Snyder, Tavi Nathanson, Samuel Funt, Arun Ahuja, Jacqueline Buros Novik, Matthew D. Hellmann, Eliza Chang, Bulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S. Robins, Elaine R. Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan Rosenberg, Dean Bajorin
bioRxiv 086843; doi: https://doi.org/10.1101/086843
Multi-omic analysis of urothelial cancer patients treated with PD-L1 blockade demonstrates the contribution of both systemic and somatic factors to the biology of response and resistance
Alexandra Snyder, Tavi Nathanson, Samuel Funt, Arun Ahuja, Jacqueline Buros Novik, Matthew D. Hellmann, Eliza Chang, Bulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S. Robins, Elaine R. Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan Rosenberg, Dean Bajorin
bioRxiv 086843; doi: https://doi.org/10.1101/086843
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