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Tuning the course of evolution on the biophysical fitness landscape of an RNA virus
Assaf Rotem, Adrian W.R. Serohijos, Connie B. Chang, Joshua T. Wolfe, Audrey E. Fischer, Thomas S. Mehoke, Huidan Zhang, Ye Tao, W. Lloyd Ung, Jeong-Mo Choi, Abimbola O. Kolawole, Stephan A. Koehler, Susan Wu, Peter M. Thielen, Naiwen Cui, Plamen A. Demirev, Nicholas S. Giacobbi, Timothy R. Julian, Kellogg Schwab, Jeffrey S. Lin, Thomas J. Smith, James M. Pipas, Christiane E. Wobus, Andrew B. Feldman, David A. Weitz, Eugene I. Shakhnovich
doi: https://doi.org/10.1101/090258
Assaf Rotem
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
Adrian W.R. Serohijos
2Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
10Département de Biochimie et Centre Robert-Cedergren en Bioinformatique et Génomique, Université de Montréal, Quebec, Canada
Connie B. Chang
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
9Chemical and Biological Engineering Department, Montana State University, Bozeman, Montana, USA
Joshua T. Wolfe
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Audrey E. Fischer
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Thomas S. Mehoke
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Huidan Zhang
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
4Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Ye Tao
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
W. Lloyd Ung
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
Jeong-Mo Choi
2Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Abimbola O. Kolawole
5Department of Microbiology and Immunology, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
Stephan A. Koehler
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
Susan Wu
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Peter M. Thielen
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Naiwen Cui
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
Plamen A. Demirev
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Nicholas S. Giacobbi
6Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA.
Timothy R. Julian
7Environmental Health Sciences and the Hopkins Water Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231, USA
12Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology (Eawag), 8600 Dübendorf, Switzerland.
Kellogg Schwab
7Environmental Health Sciences and the Hopkins Water Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231, USA
Jeffrey S. Lin
3Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, USA
Thomas J. Smith
8Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555, USA
James M. Pipas
6Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA.
Christiane E. Wobus
5Department of Microbiology and Immunology, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
Andrew B. Feldman
11Department of Emergency Medicine, Johns Hopkins Medicine, 5801 Smith Avenue, Suite 3220, Davis Building, Baltimore, MD, 21209, USA
David A. Weitz
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA
Eugene I. Shakhnovich
2Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Article usage
Posted November 28, 2016.
Tuning the course of evolution on the biophysical fitness landscape of an RNA virus
Assaf Rotem, Adrian W.R. Serohijos, Connie B. Chang, Joshua T. Wolfe, Audrey E. Fischer, Thomas S. Mehoke, Huidan Zhang, Ye Tao, W. Lloyd Ung, Jeong-Mo Choi, Abimbola O. Kolawole, Stephan A. Koehler, Susan Wu, Peter M. Thielen, Naiwen Cui, Plamen A. Demirev, Nicholas S. Giacobbi, Timothy R. Julian, Kellogg Schwab, Jeffrey S. Lin, Thomas J. Smith, James M. Pipas, Christiane E. Wobus, Andrew B. Feldman, David A. Weitz, Eugene I. Shakhnovich
bioRxiv 090258; doi: https://doi.org/10.1101/090258
Tuning the course of evolution on the biophysical fitness landscape of an RNA virus
Assaf Rotem, Adrian W.R. Serohijos, Connie B. Chang, Joshua T. Wolfe, Audrey E. Fischer, Thomas S. Mehoke, Huidan Zhang, Ye Tao, W. Lloyd Ung, Jeong-Mo Choi, Abimbola O. Kolawole, Stephan A. Koehler, Susan Wu, Peter M. Thielen, Naiwen Cui, Plamen A. Demirev, Nicholas S. Giacobbi, Timothy R. Julian, Kellogg Schwab, Jeffrey S. Lin, Thomas J. Smith, James M. Pipas, Christiane E. Wobus, Andrew B. Feldman, David A. Weitz, Eugene I. Shakhnovich
bioRxiv 090258; doi: https://doi.org/10.1101/090258
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