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Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28
Aaron Smargon, David B.T. Cox, Neena Pyzocha, Kaijie Zheng, Ian M. Slaymaker, Jonathan S. Gootenberg, Omar A. Abudayyeh, Patrick Essletzbichler, Sergey Shmakov, Kira S. Makarova, Eugene V. Koonin, View ORCID ProfileFeng Zhang
doi: https://doi.org/10.1101/092577
Aaron Smargon
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4 Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
David B.T. Cox
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5 Harvard Medical School, Boston, MA 02115
6 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Neena Pyzocha
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
6 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Kaijie Zheng
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Ian M. Slaymaker
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Jonathan S. Gootenberg
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
6 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Omar A. Abudayyeh
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
7 Department of Health Sciences and Technology Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Patrick Essletzbichler
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Sergey Shmakov
7 Department of Health Sciences and Technology Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
8 Skolkovo Institute of Science and Technology, Skolkovo 143025, Russia
Kira S. Makarova
9 National Center for Biotechnology Information National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA
Eugene V. Koonin
9 National Center for Biotechnology Information National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA
Feng Zhang
1 Broad Institute of MIT and Harvard Cambridge, Massachusetts 02142, USA
2 McGovern Institute for Brain Research at MIT Cambridge, Massachusetts 02139, USA
3 Departments of Brain and Cognitive Science and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4 Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
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Posted December 09, 2016.
Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28
Aaron Smargon, David B.T. Cox, Neena Pyzocha, Kaijie Zheng, Ian M. Slaymaker, Jonathan S. Gootenberg, Omar A. Abudayyeh, Patrick Essletzbichler, Sergey Shmakov, Kira S. Makarova, Eugene V. Koonin, Feng Zhang
bioRxiv 092577; doi: https://doi.org/10.1101/092577
Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28
Aaron Smargon, David B.T. Cox, Neena Pyzocha, Kaijie Zheng, Ian M. Slaymaker, Jonathan S. Gootenberg, Omar A. Abudayyeh, Patrick Essletzbichler, Sergey Shmakov, Kira S. Makarova, Eugene V. Koonin, Feng Zhang
bioRxiv 092577; doi: https://doi.org/10.1101/092577
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