Abstract
Horizontal gene transfer is a major driving force behind the genomic diversity seen in prokaryotes. The rac prophage in E.coli K12 encodes a putative transcription factor RacR, whose deletion is lethal. We have shown that the essentiality of racR in E.coli K12 is attributed to its role in transcriptionally repressing a toxin gene called ydaS, which is coded adjacent and divergently to racR.
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