New Results
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Jorge Berna, Jose M. Tubio, Chris E. McMurran, Adam M.H. Young, Matthew D. Young, Imran Noorani, Stephen J Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V. Peter Collins, Kieren Allinson, Michael D. Jenkinson, Rasheed Zakaria, Khaja Syed, C. Oliver Hanemann, Jemma Dunn, View ORCID ProfileMichael W. McDermott, Ramez W Kirollos, George S. Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, Ultan McDermott
doi: https://doi.org/10.1101/146811
Grace Collord
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
2Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, CB2 0QQ, UK
Patrick Tarpey
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Natalja Kurbatova
3European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
Inigo Martincorena
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Sebastian Moran
4Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain
Manuel Castro
4Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain
Tibor Nagy
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Graham Bignell
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Francesco Maura
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
5Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
6Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Jorge Berna
7Phylogenomics Lab, Edificio Torre CACTI, Campus Universitario, Universidad de Vigo, 36310 Vigo, Spain
Jose M. Tubio
7Phylogenomics Lab, Edificio Torre CACTI, Campus Universitario, Universidad de Vigo, 36310 Vigo, Spain
Chris E. McMurran
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Adam M.H. Young
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Matthew D. Young
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Imran Noorani
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Stephen J Price
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Colin Watts
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Elke Leipnitz
9Klinik und Poliklink für Neurochirurgie, “Carl Gustav Carus” Universitätsklinikum, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Matthias Kirsch
9Klinik und Poliklink für Neurochirurgie, “Carl Gustav Carus” Universitätsklinikum, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Gabriele Schackert
9Klinik und Poliklink für Neurochirurgie, “Carl Gustav Carus” Universitätsklinikum, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Danita Pearson
10Department of Pathology, Cambridge University Hospital, CB2 0QQ, Cambridge, UK
Abel Devadass
10Department of Pathology, Cambridge University Hospital, CB2 0QQ, Cambridge, UK
Zvi Ram
16Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel
V. Peter Collins
10Department of Pathology, Cambridge University Hospital, CB2 0QQ, Cambridge, UK
Kieren Allinson
10Department of Pathology, Cambridge University Hospital, CB2 0QQ, Cambridge, UK
Michael D. Jenkinson
11Department of Neurosurgery, The Walton Centre, Liverpool, L9 7LJ, UK
19Institute of Translational Medicine, University of Liverpool, Liverpool, L9 7LJ, UK
Rasheed Zakaria
11Department of Neurosurgery, The Walton Centre, Liverpool, L9 7LJ, UK
12Institute of Integrative Biology, University of Liverpool, Liverpool, L9 7LJ, UK
Khaja Syed
11Department of Neurosurgery, The Walton Centre, Liverpool, L9 7LJ, UK
12Institute of Integrative Biology, University of Liverpool, Liverpool, L9 7LJ, UK
C. Oliver Hanemann
13Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth University, Plymouth, Devon PL4 8AA, UK
Jemma Dunn
13Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth University, Plymouth, Devon PL4 8AA, UK
Michael W. McDermott
14Department of Neurosurgery, UCSF Medical Center, San Francisco, CA 94143–0112, USA
Ramez W Kirollos
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
George S. Vassiliou
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
15Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK
Manel Esteller
4Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain
17Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Catalonia, Spain
18Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
Sam Behjati
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
2Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, CB2 0QQ, UK
Alvis Brazma
3European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
Thomas Santarius
8Department of Neurosurgery, Department of Clinical Neuroscience, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Ultan McDermott
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
Abstract
Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of two distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Our analyses discern two biologically distinct variants of anaplastic meningioma with potential prognostic and therapeutic significance.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Posted June 06, 2017.
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Jorge Berna, Jose M. Tubio, Chris E. McMurran, Adam M.H. Young, Matthew D. Young, Imran Noorani, Stephen J Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V. Peter Collins, Kieren Allinson, Michael D. Jenkinson, Rasheed Zakaria, Khaja Syed, C. Oliver Hanemann, Jemma Dunn, Michael W. McDermott, Ramez W Kirollos, George S. Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, Ultan McDermott
bioRxiv 146811; doi: https://doi.org/10.1101/146811
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Jorge Berna, Jose M. Tubio, Chris E. McMurran, Adam M.H. Young, Matthew D. Young, Imran Noorani, Stephen J Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V. Peter Collins, Kieren Allinson, Michael D. Jenkinson, Rasheed Zakaria, Khaja Syed, C. Oliver Hanemann, Jemma Dunn, Michael W. McDermott, Ramez W Kirollos, George S. Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, Ultan McDermott
bioRxiv 146811; doi: https://doi.org/10.1101/146811
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