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Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation
Viet Q. Le, Roxana E. Iacob, Yuan Tian, William McConaughy, Yang Su, Bo Zhao, John R. Engen, Michelle Pirruccello-Straub, Timothy A. Springer
doi: https://doi.org/10.1101/154823
Viet Q. Le
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
Roxana E. Iacob
2Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA 02115;
Yuan Tian
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
William McConaughy
3Scholar Rock, Cambridge, MA 02139.
Yang Su
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
Bo Zhao
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
John R. Engen
2Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA 02115;
Michelle Pirruccello-Straub
3Scholar Rock, Cambridge, MA 02139.
Timothy A. Springer
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
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Posted June 23, 2017.
Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation
Viet Q. Le, Roxana E. Iacob, Yuan Tian, William McConaughy, Yang Su, Bo Zhao, John R. Engen, Michelle Pirruccello-Straub, Timothy A. Springer
bioRxiv 154823; doi: https://doi.org/10.1101/154823
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