New Results
MTAG: Multi-Trait Analysis of GWAS
Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
doi: https://doi.org/10.1101/118810
Patrick Turley
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
Raymond K. Walters
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
Omeed Maghzian
3Department of Economics, Harvard University, 1805 Cambridge Street, Cambridge, Massachusetts 02138, United States
Aysu Okbay
4Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1085, Amsterdam, 1081 HV, Netherlands
James J. Lee
5Department of Psychology, University of Minnesota, 75 E River Road, Minneapolis, Minnesota 55455, United States
Mark Alan Fontana
6Hospital for Special Surgery, 535 E 70th Street, New York, New York 10021, United States
Tuan Anh Nguyen-Viet
7Center for Economic and Social Research, University of Southern California, 635 Downey Way, Los Angeles, California 90089, United States.
Robbee Wedow
8Institute for Behavioral Genetics, University of Colorado Boulder, 1480 30th Street, Boulder, 80309, Colorado, United States.
9Institute of Behavioral Science, University of Colorado Boulder, 1440 15th Street, Boulder, 80309, Colorado, United States.
10Department of Sociology, University of Colorado Boulder, UCB 327, Boulder, 80309, Colorado, United States.
Meghan Zacher
11Department of Sociology, Harvard University, 33 Kirkland Street, Cambridge, Massachusetts, 02138, United States.
Nicholas A. Furlotte
1223andMe, Inc., Mountain View, California 94043, United States
1223andMe, Inc., Mountain View, California 94043, United States
Patrik Magnusson
13Institutionen för Medicinsk Epidemiologi och Biostatistik, Karolinska Institutet, 171 77 Stockholm, Sweden
Sven Oskarsson
14Department of Government, Uppsala Universitet, 751 20 Uppsala, Sweden
Magnus Johannesson
15Department of Economics, Stockholm School of Economics, 113 83 Stockholm, Sweden
Peter M. Visscher
16Institute for Molecular Bioscience, The University of Queensland, QLD 4072, Brisbane, Queensland, Australia
17Queensland Brain Institute, The University of Queensland, QLD 4072, Brisbane, Queensland, Australia
David Laibson
3Department of Economics, Harvard University, 1805 Cambridge Street, Cambridge, Massachusetts 02138, United States
18National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
David Cesarini
18National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
19Department of Economics and Center for Experimental Social Science, New York University, 19 W 4th Street, New York, New York 10012, United States
20Institutet för Näringslivsforskning, 114 53 Stockholm, Sweden
Benjamin M. Neale
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
Daniel J. Benjamin
7Center for Economic and Social Research, University of Southern California, 635 Downey Way, Los Angeles, California 90089, United States.
18National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
21Department of Economics, University of Southern California, 3620 South Vermont Avenue, Kaprielian Hall, 300 Los Angeles, CA 90089, United States
ABSTRACT
We introduce Multi-Trait Analysis of GWAS (MTAG), a method for joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (Neff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). Compared to 32, 9, and 13 genome-wide significant loci in the single-trait GWASs (most of which are themselves novel), MTAG increases the number of loci to 64, 37, and 49, respectively. Moreover, association statistics from MTAG yield more informative bioinformatics analyses and increase variance explained by polygenic scores by approximately 25%, matching theoretical expectations.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Posted July 03, 2017.
MTAG: Multi-Trait Analysis of GWAS
Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
bioRxiv 118810; doi: https://doi.org/10.1101/118810
MTAG: Multi-Trait Analysis of GWAS
Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
bioRxiv 118810; doi: https://doi.org/10.1101/118810
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