Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Distinct descending motor cortex pathways and their roles in movement

Michael Economo, Sarada Viswanathan, Bosiljka Tasic, Erhan Bas, Johan Winnubst, Vilas Menon, Lucas T Graybuck, Thuc Nghi Nguyen, Lihua Wang, Charles Richard Gerfen, Jayaram Chandrashekar, Hongkui Zeng, Loren Lee Looger, Karel Svoboda
doi: https://doi.org/10.1101/229260
Michael Economo
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarada Viswanathan
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bosiljka Tasic
Allen Institute for Brain Science;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erhan Bas
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johan Winnubst
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vilas Menon
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lucas T Graybuck
Allen Institute for Brain Science;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thuc Nghi Nguyen
Allen Institute for Brain Science;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lihua Wang
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles Richard Gerfen
National Institute of Mental Health
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jayaram Chandrashekar
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hongkui Zeng
Allen Institute for Brain Science;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Loren Lee Looger
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karel Svoboda
HHMI/Janelia Research Campus;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: svobodak@janelia.hhmi.org
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Activity in motor cortex predicts specific movements, seconds before they are initiated. This preparatory activity has been observed in L5 descending "pyramidal tract" (PT) neurons. A key question is how preparatory activity can be maintained without causing movement, and how preparatory activity is eventually converted to a motor command to trigger appropriate movements. We used single cell transcriptional profiling and axonal reconstructions to identify two types of PT neuron. Both types share projections to multiple targets in the basal ganglia and brainstem. One type projects to thalamic regions that connect back to motor cortex. In a delayed-response task, these neurons produced early preparatory activity that persisted until the movement. The second type projects to motor centers in the medulla and produced late preparatory activity and motor commands. These results indicate that two motor cortex output neurons are specialized for distinct roles in motor control.

Copyright 
The copyright holder for this preprint is the author/funder. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
  • Posted December 5, 2017.

Download PDF

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Distinct descending motor cortex pathways and their roles in movement
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Distinct descending motor cortex pathways and their roles in movement
Michael Economo, Sarada Viswanathan, Bosiljka Tasic, Erhan Bas, Johan Winnubst, Vilas Menon, Lucas T Graybuck, Thuc Nghi Nguyen, Lihua Wang, Charles Richard Gerfen, Jayaram Chandrashekar, Hongkui Zeng, Loren Lee Looger, Karel Svoboda
bioRxiv 229260; doi: https://doi.org/10.1101/229260
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Citation Tools
Distinct descending motor cortex pathways and their roles in movement
Michael Economo, Sarada Viswanathan, Bosiljka Tasic, Erhan Bas, Johan Winnubst, Vilas Menon, Lucas T Graybuck, Thuc Nghi Nguyen, Lihua Wang, Charles Richard Gerfen, Jayaram Chandrashekar, Hongkui Zeng, Loren Lee Looger, Karel Svoboda
bioRxiv 229260; doi: https://doi.org/10.1101/229260

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (680)
  • Biochemistry (926)
  • Bioengineering (569)
  • Bioinformatics (5038)
  • Biophysics (1612)
  • Cancer Biology (1139)
  • Cell Biology (1577)
  • Clinical Trials (58)
  • Developmental Biology (1071)
  • Ecology (1767)
  • Epidemiology (887)
  • Evolutionary Biology (3874)
  • Genetics (2665)
  • Genomics (3470)
  • Immunology (673)
  • Microbiology (2679)
  • Molecular Biology (980)
  • Neuroscience (7009)
  • Paleontology (45)
  • Pathology (138)
  • Pharmacology and Toxicology (242)
  • Physiology (315)
  • Plant Biology (972)
  • Scientific Communication and Education (275)
  • Synthetic Biology (414)
  • Systems Biology (1416)
  • Zoology (173)