Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases

View ORCID ProfileArturo Araujo, View ORCID ProfileLeah Cook, View ORCID ProfileConor Lynch, View ORCID ProfileDavid Basanta
doi: https://doi.org/10.1101/235911
Arturo Araujo
H. Lee Moffitt Cancer Center & Research Institute;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Arturo Araujo
Leah Cook
University of Nebraska Medical Center
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Leah Cook
Conor Lynch
H. Lee Moffitt Cancer Center & Research Institute;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Conor Lynch
David Basanta
H. Lee Moffitt Cancer Center & Research Institute;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Basanta
  • For correspondence: david@cancerevo.org
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Prostate cancer (PCa) impacts over 180,000 men every year in the US alone with 26,000 patients expected to succumb to the disease (cancer.gov). The primary cause of death is metastasis, with secondary lesions most commonly occurring in the skeleton. Prostate cancer to bone metastasis is an important yet poorly understood process that is difficult to explore with experimental techniques alone. To this end we have utilized a hybrid (discrete-continuum) cellular automata (HCA) model of normal bone matrix homeostasis that allowed us to investigate how metastatic PCa can disrupt the bone microenvironment. Our previously published results showed that PCa cells can recruit mesenchymal stem cells (MSCs) that give rise to bone building osteoblasts. MSCs are also thought to be complicit in the establishment of successful bone metastases (1). Here we have explored aspects of early metastatic colonization and shown that the size of PCa clusters needs to be within a specific range to become successfully established: sufficiently large to maximize success but not too large to risk failure through competition amongst cancer and stromal cells for scarce resources. Furthermore, we show that MSC recruitment can promote the establishment of a metastasis and compensate for relatively low numbers of PCa cells seeding the bone microenvironment. Combined, our results highlight the utility of computational models that capture the complex and dynamic dialogue between cells during the initiation of active metastases.

Copyright 
The copyright holder for this preprint is the author/funder. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
  • Posted December 18, 2017.

Download PDF

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases
Arturo Araujo, Leah Cook, Conor Lynch, David Basanta
bioRxiv 235911; doi: https://doi.org/10.1101/235911
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Citation Tools
Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases
Arturo Araujo, Leah Cook, Conor Lynch, David Basanta
bioRxiv 235911; doi: https://doi.org/10.1101/235911

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cancer Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (543)
  • Biochemistry (742)
  • Bioengineering (447)
  • Bioinformatics (4338)
  • Biophysics (1318)
  • Cancer Biology (893)
  • Cell Biology (1261)
  • Clinical Trials (43)
  • Developmental Biology (848)
  • Ecology (1459)
  • Epidemiology (702)
  • Evolutionary Biology (3438)
  • Genetics (2331)
  • Genomics (3015)
  • Immunology (483)
  • Microbiology (1942)
  • Molecular Biology (760)
  • Neuroscience (5770)
  • Paleontology (36)
  • Pathology (107)
  • Pharmacology and Toxicology (184)
  • Physiology (240)
  • Plant Biology (808)
  • Scientific Communication and Education (224)
  • Synthetic Biology (352)
  • Systems Biology (1195)
  • Zoology (148)