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NvERTx: A gene expression database to compare Embryogenesis and Regeneration in the sea anemone Nematostella vectensis

View ORCID ProfileJacob Warner, Vincent Guerlais, View ORCID ProfileAldine Amiel, View ORCID ProfileHereroa Johnston, View ORCID ProfileKarine Nedoncelle, View ORCID ProfileEric Rottinger
doi: https://doi.org/10.1101/242370
Jacob Warner
University Cote d'Azur / CNRS / INSERM
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Vincent Guerlais
University Cote d'Azur / CNRS / INSERM
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Aldine Amiel
University Cote d'Azur / CNRS / INSERM
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Hereroa Johnston
University Cote d'Azur / CNRS / INSERM
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Karine Nedoncelle
University Cote d'Azur / CNRS / INSERM
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Eric Rottinger
University Cote d'Azur / CNRS / INSERM
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  • For correspondence: eric.rottinger@unice.fr
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Abstract

For more than a century researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically been a difficult one to investigate since the best regenerative model systems are poor embryonic models and vice versa. Recently however, the comparison of embryogenesis and regeneration has seen renewed interest as emerging models including the sea anemone Nematostella vectensis have allowed researchers to investigate these processes in the same organism. This interest has been further fueled by the advent of high-throughput transcriptomic analyses that provide virtual mountains of data. Unfortunately much of this data remains in raw unanalyzed formats that are difficult to access or browse. Here we present Nematostella vectensis Embryogenesis and Regeneration Transcriptomics - NvERTx, the first platform for comparing gene expression during embryogenesis and regeneration. NvERTx is comprised of close to 50 RNAseq datasets spanning embryogenesis and regeneration in Nematostella. These data were used to perform a robust de novo transcriptome assembly which users can search, BLAST and plot expression of multiple genes during these two developmental processes. The site is also home to the results of gene clustering analyses, to further mine the data and identify groups of co-expressed genes. The site can be accessed at http://nvertx.kahikai.org.

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The copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
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  • Posted January 4, 2018.

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NvERTx: A gene expression database to compare Embryogenesis and Regeneration in the sea anemone Nematostella vectensis
Jacob Warner, Vincent Guerlais, Aldine Amiel, Hereroa Johnston, Karine Nedoncelle, Eric Rottinger
bioRxiv 242370; doi: https://doi.org/10.1101/242370
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NvERTx: A gene expression database to compare Embryogenesis and Regeneration in the sea anemone Nematostella vectensis
Jacob Warner, Vincent Guerlais, Aldine Amiel, Hereroa Johnston, Karine Nedoncelle, Eric Rottinger
bioRxiv 242370; doi: https://doi.org/10.1101/242370

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