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Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention
Michael Inouye, Gad Abraham, Christopher P. Nelson, Angela M. Wood, Michael J. Sweeting, Frank Dudbridge, Florence Y. Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K. Rutter, Ioanna Tzoulaki, Riyaz S. Patel, Ruth J.F. Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S. Butterworth, John Danesh, Nilesh J. Samani, for The UK Biobank CardioMetabolic Consortium CHD Working Group
doi: https://doi.org/10.1101/250712
Michael Inouye
1Systems Genomics Lab, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne 3004, Victoria, Australia
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
3Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville 3010, Victoria, Australia
Gad Abraham
1Systems Genomics Lab, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne 3004, Victoria, Australia
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
3Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville 3010, Victoria, Australia
Christopher P. Nelson
4Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Angela M. Wood
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
Michael J. Sweeting
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
Frank Dudbridge
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
5Department of Health Sciences, University of Leicester, Leicester, United Kingdom
Florence Y. Lai
4Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Stephen Kaptoge
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
6National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, United Kingdom
Marta Brozynska
1Systems Genomics Lab, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne 3004, Victoria, Australia
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
3Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville 3010, Victoria, Australia
Tingting Wang
1Systems Genomics Lab, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne 3004, Victoria, Australia
Shu Ye
4Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Thomas R Webb
4Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Martin K. Rutter
7Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
8Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Ioanna Tzoulaki
9Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, United Kingdom
10Department of Hygiene and Epidemiology, University of Ioannina, 45110, Ioannina, Greece
Riyaz S. Patel
11Institute of Cardiovascular Sciences, University College London, London, United Kingdom
12Barts Heart Centre, St Bartholomew’s Hospital, London, United Kingdom
Ruth J.F. Loos
13Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Bernard Keavney
14Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
15Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Harry Hemingway
16The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London, London, United Kingdom
John Thompson
5Department of Health Sciences, University of Leicester, Leicester, United Kingdom
Hugh Watkins
17Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, United Kingdom
18The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
Panos Deloukas
19William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom
Emanuele Di Angelantonio
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
6National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, United Kingdom
Adam S. Butterworth
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
6National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, United Kingdom
John Danesh
2MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
6National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, United Kingdom
20Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
Nilesh J. Samani
4Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Article usage
Posted January 19, 2018.
Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention
Michael Inouye, Gad Abraham, Christopher P. Nelson, Angela M. Wood, Michael J. Sweeting, Frank Dudbridge, Florence Y. Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K. Rutter, Ioanna Tzoulaki, Riyaz S. Patel, Ruth J.F. Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S. Butterworth, John Danesh, Nilesh J. Samani, for The UK Biobank CardioMetabolic Consortium CHD Working Group
bioRxiv 250712; doi: https://doi.org/10.1101/250712
Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention
Michael Inouye, Gad Abraham, Christopher P. Nelson, Angela M. Wood, Michael J. Sweeting, Frank Dudbridge, Florence Y. Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K. Rutter, Ioanna Tzoulaki, Riyaz S. Patel, Ruth J.F. Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S. Butterworth, John Danesh, Nilesh J. Samani, for The UK Biobank CardioMetabolic Consortium CHD Working Group
bioRxiv 250712; doi: https://doi.org/10.1101/250712
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