Abstract
Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17– Treg imbalance is associated with inflammatory immunosuppression in cancer. Here it is shown that in addition to ROR+Foxp3+ cells eTreg cells are a source of ex-Th17 CD4lowCD25hiCD49hiFoxp3hi (Regulatory Killer T – RKT) cells while the latest are much more suppressive. Moreover, we have identified a set of key cytokines that favor the generation and expansion ex-Th17 Foxp3low cells. These findings should accelerate efforts to define the function of this new subset of Treg cells in the immune response to cancer.
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