Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Genetic analysis of Sephardic ancestry in the Iberian Peninsula

Miguel M Alvarez-Alvarez, Neil Risch, Christopher R Gignoux, Scott Huntsman, Elad Ziv, Laura Fejerman, Maria Esther Esteban, Magdalena Gaya-Vidal, Beatriz Sobrino, Francesca Brisighelli, Nourdin Harich, Fulvio Cruciani, Hassen Chaabani, Angel Carracedo, Pedro Moral, Esteban Gonzalez Burchard, Marc Via, Georgios Athanasiadis
doi: https://doi.org/10.1101/325779
Miguel M Alvarez-Alvarez
University of Barcelona;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mmalvarez@ub.edu
Neil Risch
University of California San Francisco;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher R Gignoux
University of Colorado;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Scott Huntsman
University of California San Francisco;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elad Ziv
University of California San Francisco;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Fejerman
University of California San Francisco;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Esther Esteban
Universitat de Barcelona;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Magdalena Gaya-Vidal
University of Porto;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Beatriz Sobrino
University of Santiago de Compostela;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesca Brisighelli
Catholic University of the Sacred Heart;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nourdin Harich
University Chouaib Doukkali;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fulvio Cruciani
Sapienza University of Rome;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hassen Chaabani
University of Monastir;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Angel Carracedo
University of Santiago de Compostela;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pedro Moral
Universitat de Barcelona;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Esteban Gonzalez Burchard
University of California San Francisco;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marc Via
Universitat de Barcelona;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georgios Athanasiadis
University of Copenhagen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Info/History
  • Metrics
  • Data Supplements
  • Preview PDF
Loading

Abstract

The Sephardim are a major Jewish ethnic division whose origins can be traced back to the Iberian Peninsula. We used genome-wide SNP data to investigate the degree of Sephardic admixture in seven populations from the Iberian Peninsula and surrounding regions in the aftermath of their religious persecution starting in the late 14th century. To this end, we used Eastern Mediterranean (from South Italy, Greece and Israel) and North African (Tunisian and Moroccan) populations as proxies for the major ancestral components found in the target populations and carried out unlinked- and linked-marker analyses on the available genetic data. We report evidence of Sephardic ancestry in some of our Iberian samples, as well as in North Italy and Tunisia. We find the Sephardic admixture to be more recent relative to the Berber admixture following an out-of-Iberia geographic dispersal, suggesting Sephardic gene flow from Spain outwards. We also report some of the challenges in assigning Sephardic ancestry to potentially admixed individuals due to the lack of a clear genetic signature.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
  • Posted May 18, 2018.

Download PDF

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Genetic analysis of Sephardic ancestry in the Iberian Peninsula
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Genetic analysis of Sephardic ancestry in the Iberian Peninsula
Miguel M Alvarez-Alvarez, Neil Risch, Christopher R Gignoux, Scott Huntsman, Elad Ziv, Laura Fejerman, Maria Esther Esteban, Magdalena Gaya-Vidal, Beatriz Sobrino, Francesca Brisighelli, Nourdin Harich, Fulvio Cruciani, Hassen Chaabani, Angel Carracedo, Pedro Moral, Esteban Gonzalez Burchard, Marc Via, Georgios Athanasiadis
bioRxiv 325779; doi: https://doi.org/10.1101/325779
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Genetic analysis of Sephardic ancestry in the Iberian Peninsula
Miguel M Alvarez-Alvarez, Neil Risch, Christopher R Gignoux, Scott Huntsman, Elad Ziv, Laura Fejerman, Maria Esther Esteban, Magdalena Gaya-Vidal, Beatriz Sobrino, Francesca Brisighelli, Nourdin Harich, Fulvio Cruciani, Hassen Chaabani, Angel Carracedo, Pedro Moral, Esteban Gonzalez Burchard, Marc Via, Georgios Athanasiadis
bioRxiv 325779; doi: https://doi.org/10.1101/325779

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genomics
Subject Areas
All Articles
  • Animal Behavior and Cognition (815)
  • Biochemistry (1128)
  • Bioengineering (718)
  • Bioinformatics (5733)
  • Biophysics (1946)
  • Cancer Biology (1383)
  • Cell Biology (1961)
  • Clinical Trials (71)
  • Developmental Biology (1340)
  • Ecology (2060)
  • Epidemiology (1096)
  • Evolutionary Biology (4336)
  • Genetics (3048)
  • Genomics (3931)
  • Immunology (840)
  • Microbiology (3301)
  • Molecular Biology (1221)
  • Neuroscience (8408)
  • Paleontology (62)
  • Pathology (169)
  • Pharmacology and Toxicology (304)
  • Physiology (401)
  • Plant Biology (1143)
  • Scientific Communication and Education (318)
  • Synthetic Biology (469)
  • Systems Biology (1601)
  • Zoology (211)