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Application of mechanistic methods to clinical trials in multiple sclerosis: the simvastatin case
View ORCID ProfileArman Eshaghi, View ORCID ProfileRogier A Kievit, Ferran Prados, Carole Sudre, Jennifer Nicholas, M Jorge Cardoso, Dennis Chan, Richard Nicholas, Sebastien Ourselin, John Greenwood, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Jeremy Chataway, Olga Ciccarelli
doi: https://doi.org/10.1101/343442
Arman Eshaghi
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
2Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, UK
Rogier A Kievit
3Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, England, and Berlin, Germany
Ferran Prados
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
4Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, UK
Carole Sudre
4Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, UK
Jennifer Nicholas
5London School of Hygiene and Tropical Medicine, London, UK
M Jorge Cardoso
4Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, UK
Dennis Chan
6Department of Clinical Neurosciences, University of Cambridge, UK
Richard Nicholas
7Division of Brain Sciences, Imperial College London, UK8UCL Institute of Ophthalmology, University College London, UK
Sebastien Ourselin
4Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, UK
John Greenwood
8UCL Institute of Ophthalmology, University College London, UK
Alan J Thompson
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
9National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK
Daniel C Alexander
2Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, UK
Frederik Barkhof
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
9National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK
10Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Jeremy Chataway
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
Olga Ciccarelli
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
9National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK
Article usage
Posted June 11, 2018.
Application of mechanistic methods to clinical trials in multiple sclerosis: the simvastatin case
Arman Eshaghi, Rogier A Kievit, Ferran Prados, Carole Sudre, Jennifer Nicholas, M Jorge Cardoso, Dennis Chan, Richard Nicholas, Sebastien Ourselin, John Greenwood, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Jeremy Chataway, Olga Ciccarelli
bioRxiv 343442; doi: https://doi.org/10.1101/343442
Application of mechanistic methods to clinical trials in multiple sclerosis: the simvastatin case
Arman Eshaghi, Rogier A Kievit, Ferran Prados, Carole Sudre, Jennifer Nicholas, M Jorge Cardoso, Dennis Chan, Richard Nicholas, Sebastien Ourselin, John Greenwood, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Jeremy Chataway, Olga Ciccarelli
bioRxiv 343442; doi: https://doi.org/10.1101/343442
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