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Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies
View ORCID ProfileMashaal Sohail, Robert M. Maier, Andrea Ganna, Alexander Bloemendal, Alicia R. Martin, Michael C. Turchin, Charleston W.K. Chiang, Joel N. Hirschhorn, Mark Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil Sunyaev
doi: https://doi.org/10.1101/355057
Mashaal Sohail
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Robert M. Maier
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Andrea Ganna
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
7Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Alexander Bloemendal
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Alicia R. Martin
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Michael C. Turchin
8Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, USA
9Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
Charleston W.K. Chiang
10Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Joel N. Hirschhorn
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
11Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts, USA
12Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, Massachusetts, USA
Mark Daly
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
7Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Nick Patterson
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
13Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Benjamin Neale
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Iain Mathieson
14Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19103, USA
David Reich
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
13Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
15Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115,USA
Shamil Sunyaev
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
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Posted June 25, 2018.
Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies
Mashaal Sohail, Robert M. Maier, Andrea Ganna, Alexander Bloemendal, Alicia R. Martin, Michael C. Turchin, Charleston W.K. Chiang, Joel N. Hirschhorn, Mark Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil Sunyaev
bioRxiv 355057; doi: https://doi.org/10.1101/355057
Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies
Mashaal Sohail, Robert M. Maier, Andrea Ganna, Alexander Bloemendal, Alicia R. Martin, Michael C. Turchin, Charleston W.K. Chiang, Joel N. Hirschhorn, Mark Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil Sunyaev
bioRxiv 355057; doi: https://doi.org/10.1101/355057
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