Abstract
In this report, the urinary proteome from a patient-derived xenograft (PDX) model was compared at the peptide level to study the origins of urinary proteins in tumor-bearing nude mice. Urine was collected from the PDX mice before and after tumor implantation. A total of 515 mouse proteins were identified, of which 8 were differential proteins. Seventy-eight unambiguous human peptides from 42 human proteins were identified in the tumor-bearing group. Compared with the differential urinary proteins from the tumor-bearing immuno-competent rats, the differential proteins in the urine from the PDX model had no host immune response proteins in the very early stage urine in the tumor-bearing immuno-competent rat model.
Footnotes
Funding Information This work was supported by the National Key Research and Development Program of China (2016YFC1306300); Beijing Natural Science Foundation (7173264,7172076); funds from Beijing Normal University (11100704, 10300-310421102) and pumch-2016-2.27. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.