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- July 13, 2018.
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Author Information
- Stefan C. Dentro1,2,3,#,
- Ignaty Leshchiner4,#,
- Kerstin Haase1,#,
- Maxime Tarabichi1,2,#,
- Jeff Wintersinger5,#,
- Amit G. Deshwar5,#,
- Kaixian Yu6,#,
- Yulia Rubanova5,#,
- Geoff Macintyre8,#,
- Ignacio Vázquez-García2,7,
- Kortine Kleinheinz9,10,
- Dimitri G. Livitz4,
- Salem Malikic11,
- Nilgun Donmez11,
- Subhajit Sengupta12,
- Jonas Demeulemeester1,13,
- Pavana Anur14,
- Clemency Jolly1,
- Marek Cmero15,
- Daniel Rosebrock4,
- Steven Schumacher4,
- Yu Fan6,
- Matthew Fittall1,
- Ruben M. Drews8,
- Xiaotong Yao16,17,
- Juhee Lee18,
- Matthias Schlesner9,
- Hongtu Zhu6,
- David J. Adams2,
- Gad Getz4,
- Paul C. Boutros5,19,
- Marcin Imielinski16,17,
- Rameen Beroukhim4,
- S. Cenk Sahinalp20,
- Yuan Ji12,21,
- Martin Peifer22,
- Inigo Martincorena2,
- Florian Markowetz8,
- Ville Mustonen23,
- Ke Yuan8,24,
- Moritz Gerstung25,
- Paul T. Spellman14,
- Wenyi Wang6,#,
- Quaid D. Morris5,#,
- David C. Wedge3,26,#,* and
- Peter Van Loo1,13,#,*
- 1The Francis Crick Institute, London, United Kingdom;
- 2Wellcome Trust Sanger Institute, Cambridge, United Kingdom;
- 3Big Data Institute, University of Oxford, Oxford, United Kingdom;
- 4Broad Institute of MIT and Harvard, Cambridge, MA, USA;
- 5University of Toronto, Toronto, Canada;
- 6The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
- 7University of Cambridge, Cambridge, United Kingdom;
- 8Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom;
- 9German Cancer Research Center (DKFZ), Heidelberg, Germany;
- 10Heidelberg University, Heidelberg, Germany;
- 11Simon Fraser University, Vancouver, Canada;
- 12NorthShore University HealthSystem, Evanston, IL, USA;
- 13Department of Human Genetics, University of Leuven, Leuven, Belgium;
- 14Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA;
- 15University of Melbourne, Melbourne, Australia;
- 16Weill Cornell Medicine, New York, NY, USA;
- 17New York Genome Center, New York, NY, USA;
- 18University of California Santa Cruz, Santa Cruz, CA, USA;
- 19Ontario Institute for Cancer Research, Toronto, Canada;
- 20Indiana University, Bloomington, IN, USA;
- 21The University of Chicago, Chicago, IL, USA;
- 22University of Cologne, Cologne, Germany;
- 23University of Helsinki, Helsinki, Finland;
- 24University of Glasgow, Glasgow G12 8RZ, United Kingdom;
- 25European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom;
- 26Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.
- 27A list of members of the PCAWG Evolution and Heterogeneity Working Group can be found at the end of the manuscript.
- ↵*To whom correspondence may be addressed: David C. Wedge, Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, United Kingdom. Tel: +44 (0) 1865 289 610, e-mail: David.Wedge{at}bdi.ox.ac.uk. Peter Van Loo, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, United Kingdom. Tel: +44 (0) 20 3796 1719, e-mail: Peter.VanLoo{at}crick.ac.uk.
- 1 The Francis Crick Institute, London NW1 1AT, United Kingdom;
- 2 Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom;
- 3 Big Data Institute, University of Oxford, Oxford OX3 7LF, United Kingdom;
- 4 Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;
- 5 European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, United Kingdom;
- 6 University of Toronto, Toronto, ON M5S 3E1, Canada;
- 7 Vector Institute, Toronto, ON M5G 1L7, Canada;
- 8 The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;
- 9 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;
- 10 Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97231, USA;
- 11 Dana-Farber Cancer Institute, Boston, MA 02215, USA;
- 12 Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;
- 13 Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia;
- 14 University of Melbourne, Melbourne, VIC 3010, Australia;
- 15 Walter + Eliza Hall Institute, Melbourne, VIC 3000, Australia;
- 16 University of Cologne, 50931 Cologne, Germany;
- 17 Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium;
- 18 Simon Fraser University, Burnaby, BC V5A 1S6, Canada;
- 19 Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada;
- 20 German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
- 21 Heidelberg University, 69120 Heidelberg, Germany;
- 22 Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts 02129, USA;
- 23 Massachusetts General Hospital, Department of Pathology, Boston, Massachusetts 02114, USA;
- 24 Harvard Medical School, Boston, 02215, USA;
- 25 Weill Cornell Medicine, New York, NY 10065, USA;
- 26 New York Genome Center, New York, NY 10013, USA;
- 27 University of Ljubljana, 1000 Ljubljana, Slovenia;
- 28 NorthShore University HealthSystem, Evanston, IL 60201, USA;
- 29 The University of Chicago, Chicago, IL 60637, USA;
- 30 University of California Santa Cruz, Santa Cruz, CA 95064, USA;
- 31 University of Cambridge, Cambridge CB2 0QQ, United Kingdom;
- 32 University of Helsinki, 00014 Helsinki, Finland;
- 33 Carleton College, Northfield, MN 55057, USA;
- 34 Princeton University, Princeton, NJ 08540, USA;
- 35 Indiana University, Bloomington, IN 47405, USA;
- 36 Korea University, Seoul, 02481, Republic of Korea;
- 37 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA;
- 38 University of Glasgow, Glasgow G12 8RZ, United Kingdom;
- 39 Oxford NIHR Biomedical Research Centre, Oxford OX4 2PG, United Kingdom.