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HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma
Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
doi: https://doi.org/10.1101/388041
Yilong Zou
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
8Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Michael J. Palte
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Amy A. Deik
2Metabolomics Platform, Broad Institute, Cambridge, MA 02142, USA
Haoxin Li
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
8Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
John K. Eaton
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Wenyu Wang
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Yuen-Yi Tseng
3Cancer Program, Broad Institute, Cambridge, MA 02142, USA
Rebecca Deasy
3Cancer Program, Broad Institute, Cambridge, MA 02142, USA
Maria Alimova
4Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA
Vlado Dančík
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Elizaveta S. Leshchiner
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
3Cancer Program, Broad Institute, Cambridge, MA 02142, USA
Vasanthi S. Viswanathan
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Sabina Signoretti
6Department of Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Toni K. Choueiri
7Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Jesse S. Boehm
3Cancer Program, Broad Institute, Cambridge, MA 02142, USA
Bridget K. Wagner
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
John Doench
5Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA
Clary B. Clish
2Metabolomics Platform, Broad Institute, Cambridge, MA 02142, USA
Paul A. Clemons
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Stuart L. Schreiber
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
8Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Article usage
Posted August 09, 2018.
HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma
Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
bioRxiv 388041; doi: https://doi.org/10.1101/388041
HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma
Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
bioRxiv 388041; doi: https://doi.org/10.1101/388041
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