ABSTRACT
The Network of Cancer Genes (NCG) is a manually curated repository of 2,372 genes whose somatic modification is known or predicted to have a cancer driver role. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of 119 cancer types in 31 primary sites, for a total of 34,905 cancer donors. In addition to collecting cancer genes, NCG annotates their systems-level properties, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, protein function and essentiality. NCG offers a comprehensive and up-to-date collection of cancer genes and is accessible at http://ncg.kcl.ac.uk/.
LIST OF ABBREVIATIONS
- CCLE
- Cancer Cell Line Encyclopedia
- CLP
- Cell Line Project (COSMIC)
- GNE
- Genentech
- ICGC
- International Cancer Genome Consortium
- miRNA
- microRNA
- NCG
- Network of Cancer Genes
- OG
- Oncogene
- RPKM
- Reads Per Kilobase Million
- TCGA
- The Cancer Genome Atlas
- TPM
- Transcripts Per Million
- TSG
- Tumour Suppressor Gene
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.