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- September 14, 2018.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Niamh Mullins1,2,
- Tim B. Bigdeli3,4,
- Anders D Børglum5,6,7,
- Jonathan R I Coleman1,
- Ditte Demontis5,6,7,
- Ayman H. Fanous3,4,
- Divya Mehta8,9,
- Robert A. Power1,
- Stephan Ripke10,11,12,
- Eli A Stahl12,13,14,
- Anna Starnawska5,6,7,
- Adebayo Anjorin15,
- Aiden Corvin16,
- Alan R Sanders17,18,
- Andreas J Forstner19,20,21,22,23,
- Andreas Reif24,
- Anna C Koller22,23,
- Beata Świątkowska25,
- Bernhard T Baune26,
- Bertram Müller-Myhsok27,28,29,
- Bettina Konte30,
- Brenda WJH Penninx31,
- Carlos Pato32,33,
- Clement Zai34,
- Dan Rujescu30,35,
- Digby Quested36,
- Douglas F Levinson37,
- Elisabeth B Binder28,38,
- Enda M Byrne39,
- Esben Agerbo7,40,41,
- Fabian Streit42,
- Fermin Mayoral43,
- Frank Bellivier44,45,46,47,
- Franziska Degenhardt22,23,
- Gerome Breen1,48,
- Gunnar Morken49,50,
- Gustavo Turecki51,
- Guy A Rouleau52,53,
- Hans J Grabe54,
- Henry Völzke55,
- Ina Giegling30,35,
- Ingrid Agartz56,57,58,
- Ingrid Melle59,60,
- Jacob Lawrence61,
- James B Potash62,
- James TR Walters63,
- Jana Strohmaier42,
- Jianxin Shi64,
- Joanna Hauser65,
- Joanna M Biernacka66,
- John B Vincent34,
- John Kelsoe67,
- John S Strauss34,68,
- Jolanta Lissowska69,
- Jonathan Pimm70,
- Jordan W Smoller71,72,73,
- José Guzman Parra43,
- Klaus Berger74,
- Laura J Scott75,
- M. Helena Azevedo76,
- Maciej Trzaskowski39,
- Manolis Kogevinas77,
- Marcella Rietschel78,
- Marco Boks79,
- Marcus Ising80,
- Maria Grigoroiu-Serbanescu81,
- Marian L Hamshere82,
- Marion Leboyer44,83,84,
- Mark Frye85,
- Markus M Nöthen22,23,
- Martin Alda86,87,
- Martin Preisig88,
- Merete Nordentoft7,89,
- Michael Boehnke75,
- Michael C O’Donovan82,
- Michael J Owen82,
- Michele T Pato33,
- Miguel Renteria90,
- Monika Budde91,
- Myrna M Weissman92,93,
- Naomi R Wray8,39,
- Nicholas Bass70,
- Olav B Smeland94,95,96,
- Ole A Andreassen95,96,
- Ole Mors7,97,
- Pablo V Gejman17,18,
- Pamela Sklar13,14,98,
- Patrick McGrath92,
- Per Hoffmann20,22,23,99,
- Peter McGuffin1,
- Phil H Lee10,73,100,
- René S Kahn14,79,
- Roel A Ophoff101,102,
- Rolf Adolfsson103,
- Sandra Van der Auwera54,
- Srdjan Djurovic104,105,
- Stanley I Shyn106,
- Stefan Kloiber34,68,80,
- Stefanie Heilmann-Heimbach107,
- Stéphane Jamain83,108,
- Steven P Hamilton109,
- Susan L McElroy110,
- Susanne Lucae80,
- Sven Cichon20,22,99,111,
- Thomas G Schulze112,
- Thomas Hansen7,113,
- Thomas Werge7,114,115,
- Tracy M Air116,
- Vishwajit Nimgaonkar117,
- Vivek Appadurai7,
- Wiepke Cahn118,
- Yuri Milaneschi31,
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium,
- Kenneth S Kendler4,
- Andrew McQuillin70 and
- Cathryn M Lewis1,119
- 1Social Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- 2Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- 3Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, US
- 4Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US
- 5Department of Biomedicine, Aarhus University, Aarhus, DK
- 6iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- 7iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- 8Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- 9School of Psychology and Counseling, Queensland University of Technology, Brisbane, QLD, AU
- 10Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- 11Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, DE
- 12Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- 13Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- 14Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- 15Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, GB
- 16Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IE
- 17Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, US
- 18Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, IL, US
- 19Department of Psychiatry (UPK), University of Basel, Basel, CH
- 20Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- 21Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, CH
- 22Institute of Human Genetics, University of Bonn, Bonn, DE
- 23Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- 24Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, DE
- 25Nofer Institute of Occupational Medicine, Lodz, PO
- 26Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, AU
- 27University of Liverpool, Liverpool, GB
- 28Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE
- 29Munich Cluster for Systems Neurology (SyNergy), Munich, DE
- 30Department of Psychiatry, University of Halle, Halle, DE
- 31Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- 32College of Medicine Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- 33Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- 34Centre for Addiction and Mental Health, Toronto, ON, CA
- 35Department of Psychiatry, University of Munich, Munich, DE
- 36Department of Psychiatry, University of Oxford, Oxford, GB
- 37Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, US
- 38Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, US
- 39Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- 40Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK
- 41National Centre for Register-Based Research, Aarhus University, Aarhus, DK
- 42Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- 43Mental Health Department, University Regional Hospital. Biomedicine Institute (IBIMA), Málaga, ES
- 44Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, FR
- 45Paris Bipolar and TRD Expert Centres, FondaMental Foundation, Paris, FR
- 46UMR-S1144 Team 1: Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, FR
- 47Psychiatry, Université Paris Diderot, Paris, FR
- 48NIHR Maudsley Biomedical Research Centre, King’s College London, London, GB
- 49Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology - NTNU, Trondheim, NO
- 50Psychiatry, St Olavs University Hospital, Trondheim, NO
- 51Department of Psychiatry, McGill University, Montreal, QC, CA
- 52Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal, QC, CA
- 53Montreal Neurological Institute and Hospital, Montreal, QC, CA
- 54Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- 55Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- 56Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NO
- 57NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, NO
- 58Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, SE
- 59Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- 60Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, NO
- 61Psychiatry, North East London NHS Foundation Trust, Ilford, 0, GB
- 62Psychiatry, University of Iowa, Iowa City, IA, US
- 63MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, GB
- 64Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, US
- 65Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, PL
- 66Health Sciences Research, Mayo Clinic, Rochester, MN, US
- 67Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- 68Department of Psychiatry, University of Toronto, Toronto, ON, CA
- 69Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, PL
- 70Division of Psychiatry, University College London, London, GB
- 71Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US
- 72Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, US
- 73Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- 74Institute of Epidemiology and Social Medicine, University of Münster, Münster, Nordrhein-Westfalen, DE
- 75Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, US
- 76Department of Psychiatry, University of Coimbra, Coimbra, PT
- 77Center for Research in Environmental Epidemiology (CREAL), Barcelona, ES
- 78Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- 79Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- 80Max Planck Institute of Psychiatry, Munich, DE
- 81Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, RO
- 82Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- 83Faculté de Médecine, Université Paris Est, Créteil, FR
- 84INSERM, Paris, FR
- 85Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, US
- 86Department of Psychiatry, Dalhousie University, Halifax, NS, CA
- 87National Institute of Mental Health, Klecany, CZ
- 88Department of Psychiatry, University Hospital of Lausanne, Prilly, Vaud, CH
- 89Mental Health Center Copenhagen, Copenhagen Universtity Hospital, Copenhagen, DK
- 90Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- 91Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Munich, DE
- 92Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, US
- 93Division of Epidemiology, New York State Psychiatric Institute, New York, NY, US
- 94Department of Neurosciences, University of California San Diego, La Jolla, CA, US
- 95Div Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- 96NORMENT, University of Oslo, Oslo, NO
- 97Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, DK
- 98Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, US
- 99Department of Biomedicine, University of Basel, Basel, CH
- 100Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- 101Jane and Terry Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, US
- 102UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- 103Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, SE
- 104NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, NO
- 105Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, NO
- 106Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, US
- 107Department of Biomedicine, University of Basel, Basel, CH
- 108Psychiatrie Translationnelle, Inserm U955, Créteil, FR
- 109Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, US
- 110Research Institute, Lindner Center of HOPE, Mason, OH, US
- 111Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, DE
- 112Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Niedersachsen, DE
- 113Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Copenhagen, DK
- 114Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK
- 115Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK
- 116Discipline of Psychiatry, University of Adelaide, Adelaide, SA, AU
- 117Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, US
- 118Department of Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- 119Department of Medical & Molecular Genetics, King’s College London, London, GB
- Correspondence Niamh Mullins, Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, One Gustave L. Levy Place, Box 1498, New York, NY, 10029. niamh.mullins{at}mssm.edu