Abstract
Building on our previous work and expanding the range of species consid-ered, we highlight the prevalence of signals of positive selection on genes coding for glutamate receptors (most notably kainate and metabotropic receptors) in domesticated species and anatomically modern humans. Re-lying on their expression in the central nervous system and phenotypes associated with mutations in these genes, we claim that regulatory changes in kainate and metabotropic receptor genes have led to alterations in lim-bic function and Hypothalamic-Pituitary-Adrenal axis regulation, with potential implications for the emergence of unique social behaviors and communicative abilities in (self-)domesticated species.
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