New Results
Genetic control of variability in subcortical and intracranial volumes
Aldo Córdova-Palomera, Dennis van der Meer, Tobias Kaufmann, Francesco Bettella, Yunpeng Wang, Dag Alnæs, Nhat Trung Doan, Ingrid Agartz, Alessandro Bertolino, Jan K. Buitelaar, David Coynel, Srdjan Djurovic, Erlend S. Dørum, Thomas Espeseth, Leonardo Fazio, Barbara Franke, Oleksandr Frei, Asta Håberg, Stephanie Le Hellard, Erik G. Jönsson, Knut K. Kolskår, Martina J. Lund, Torgeir Moberget, Jan E. Nordvik, Lars Nyberg, Andreas Papassotiropoulos, Giulio Pergola, Dominique de Quervain, Antonio Rampino, Genevieve Richard, Jaroslav Rokicki, Anne-Marthe Sanders, Emanuel Schwarz, Olav B. Smeland, Vidar M. Steen, Jostein Starrfelt, Ida E. Sønderby, Kristine M. Ulrichsen, Ole A. Andreassen, Lars T. Westlye, for the Alzheimer’s Disease Neuroimaging Initiative, for the Pediatric Imaging, Neurocognition and Genetics Study
doi: https://doi.org/10.1101/443549
Aldo Córdova-Palomera
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Dennis van der Meer
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Tobias Kaufmann
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Francesco Bettella
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Yunpeng Wang
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Dag Alnæs
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Nhat Trung Doan
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Ingrid Agartz
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
2Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway
3Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
Alessandro Bertolino
4Institute of Psychiatry, Bari University Hospital, Bari, Italy
5Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Jan K. Buitelaar
6Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
7Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
David Coynel
8Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland
9Division of Cognitive Neuroscience, University of Basel, Basel, Switzerland
Srdjan Djurovic
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Erlend S. Dørum
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Thomas Espeseth
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
Leonardo Fazio
5Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Barbara Franke
12Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
Oleksandr Frei
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Asta Håberg
13Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway
14Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim, Norway
Stephanie Le Hellard
15NORMENT, K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway
Erik G. Jönsson
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
3Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
Knut K. Kolskår
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Martina J. Lund
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Torgeir Moberget
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Jan E. Nordvik
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Lars Nyberg
16Department of Radiation Sciences, Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
Andreas Papassotiropoulos
8Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland
17Division of Molecular Neuroscience, University of Basel, Basel, Switzerland
18Life Sciences Training Facility, Department Biozentrum, University of Basel, Basel, Switzerland
Giulio Pergola
5Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Dominique de Quervain
8Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland
9Division of Cognitive Neuroscience, University of Basel, Basel, Switzerland
Antonio Rampino
5Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Genevieve Richard
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Jaroslav Rokicki
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
Anne-Marthe Sanders
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Emanuel Schwarz
19Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
Olav B. Smeland
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Vidar M. Steen
15NORMENT, K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway
20Dr. E. Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway
Jostein Starrfelt
21Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo, Norway
Ida E. Sønderby
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Kristine M. Ulrichsen
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
11Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Ole A. Andreassen
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
Lars T. Westlye
1NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway
10Department of Psychology, University of Oslo, Oslo, Norway
22Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at:
23Data used in preparation of this article were obtained from the Pediatric Imaging, Neurocognition and Genetics Study (PING) database (). As such, the investigators within PING contributed to the design and implementation of PING and/or provided data but did not participate in analysis or writing of this report. A complete listing of PING investigators can be found at
Abstract
Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here we identify genetic loci associated with phenotypic variability in key brain structures: amygdala, pallidum, and intracranial volumes. Variance-controlling loci included genes with a documented role in brain and mental health and were not associated with the mean anatomical volumes.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted October 15, 2018.
Genetic control of variability in subcortical and intracranial volumes
Aldo Córdova-Palomera, Dennis van der Meer, Tobias Kaufmann, Francesco Bettella, Yunpeng Wang, Dag Alnæs, Nhat Trung Doan, Ingrid Agartz, Alessandro Bertolino, Jan K. Buitelaar, David Coynel, Srdjan Djurovic, Erlend S. Dørum, Thomas Espeseth, Leonardo Fazio, Barbara Franke, Oleksandr Frei, Asta Håberg, Stephanie Le Hellard, Erik G. Jönsson, Knut K. Kolskår, Martina J. Lund, Torgeir Moberget, Jan E. Nordvik, Lars Nyberg, Andreas Papassotiropoulos, Giulio Pergola, Dominique de Quervain, Antonio Rampino, Genevieve Richard, Jaroslav Rokicki, Anne-Marthe Sanders, Emanuel Schwarz, Olav B. Smeland, Vidar M. Steen, Jostein Starrfelt, Ida E. Sønderby, Kristine M. Ulrichsen, Ole A. Andreassen, Lars T. Westlye, for the Alzheimer’s Disease Neuroimaging Initiative, for the Pediatric Imaging, Neurocognition and Genetics Study
bioRxiv 443549; doi: https://doi.org/10.1101/443549
Genetic control of variability in subcortical and intracranial volumes
Aldo Córdova-Palomera, Dennis van der Meer, Tobias Kaufmann, Francesco Bettella, Yunpeng Wang, Dag Alnæs, Nhat Trung Doan, Ingrid Agartz, Alessandro Bertolino, Jan K. Buitelaar, David Coynel, Srdjan Djurovic, Erlend S. Dørum, Thomas Espeseth, Leonardo Fazio, Barbara Franke, Oleksandr Frei, Asta Håberg, Stephanie Le Hellard, Erik G. Jönsson, Knut K. Kolskår, Martina J. Lund, Torgeir Moberget, Jan E. Nordvik, Lars Nyberg, Andreas Papassotiropoulos, Giulio Pergola, Dominique de Quervain, Antonio Rampino, Genevieve Richard, Jaroslav Rokicki, Anne-Marthe Sanders, Emanuel Schwarz, Olav B. Smeland, Vidar M. Steen, Jostein Starrfelt, Ida E. Sønderby, Kristine M. Ulrichsen, Ole A. Andreassen, Lars T. Westlye, for the Alzheimer’s Disease Neuroimaging Initiative, for the Pediatric Imaging, Neurocognition and Genetics Study
bioRxiv 443549; doi: https://doi.org/10.1101/443549
Subject Area
Subject Areas
- Biochemistry (11752)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14974)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28097)
- Molecular Biology (11594)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)