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History
- October 19, 2018.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Urmo Võsa*,#,1,2,
- Annique Claringbould*,#,1,
- Harm-Jan Westra**,1,
- Marc Jan Bonder**,1,
- Patrick Deelen**,1,3,
- Biao Zeng4,
- Holger Kirsten5,
- Ashis Saha6,
- Roman Kreuzhuber7,8,
- Silva Kasela2,
- Natalia Pervjakova2,
- Isabel Alvaes9,
- Marie-Julie Fave9,
- Mawusse Agbessi9,
- Mark Christiansen10,
- Rick Jansen11,
- Ilkka Seppälä12,
- Lin Tong13,
- Alexander Teumer14,
- Katharina Schramm15,16,
- Gibran Hemani17,
- Joost Verlouw18,
- Hanieh Yaghootkar19,
- Reyhan Sönmez20,21,
- Andrew Brown22,23,21,
- Viktorija Kukushkina2,
- Anette Kalnapenkis2,
- Sina Rüeger24,
- Eleonora Porcu24,
- Jaanika Kronberg-Guzman2,
- Johannes Kettunen25,
- Joseph Powell26,
- Bernett Lee27,
- Futao Zhang28,
- Wibowo Arindrarto29,
- Frank Beutner30,
- BIOS Consortium,
- Harm Brugge1,
- i2QTL Consortium,
- Julia Dmitreva31,
- Mahmoud Elansary31,
- Benjamin P. Fairfax32,
- Michel Georges31,
- Bastiaan T. Heijmans29,
- Mika Kähönen33,
- Yungil Kim34,35,
- Julian C. Knight32,
- Peter Kovacs36,
- Knut Krohn37,
- Shuang Li1,
- Markus Loeffler5,
- Urko M. Marigorta4,
- Hailang Mei38,
- Yukihide Momozawa31,39,
- Martina Müller-Nurasyid15,16,40,
- Matthias Nauck41,
- Michel Nivard42,
- Brenda Penninx11,
- Jonathan Pritchard43,
- Olli Raitakari44,
- Olaf Rotzchke27,
- Eline P. Slagboom29,
- Coen D.A. Stehouwer45,
- Michael Stumvoll46,
- Patrick Sullivan47,
- Peter A.C. ‘t Hoen48,
- Joachim Thiery49,
- Anke Tönjes46,
- Jenny van Dongen11,
- Maarten van Iterson29,
- Jan Veldink50,
- Uwe Völker51,
- Cisca Wijmenga1,
- Morris Swertz3,
- Anand Andiappan27,
- Grant W. Montgomery52,
- Samuli Ripatti53,
- Markus Perola54,
- Zoltan Kutalik24,
- Emmanouil Dermitzakis22,23,21,
- Sven Bergmann20,21,
- Timothy Frayling19,
- Joyce van Meurs18,
- Holger Prokisch55,56,
- Habibul Ahsan13,
- Brandon Pierce13,
- Terho Lehtimäki12,
- Dorret Boomsma11,
- Bruce M. Psaty10,57,
- Sina A. Gharib58,10,
- Philip Awadalla9,
- Lili Milani2,
- Willem Ouwehand7,59,
- Kate Downes7,
- Oliver Stegle8,60,61,
- Alexis Battle62,
- Jian Yang28,63,
- Peter M. Visscher28,
- Markus Scholz5,
- Gregory Gibson4,
- Tõnu Esko2 and
- Lude Franke#,1
- 1 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
- 2 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia
- 3 Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
- 4 School of Biological Sciences, Georgia Tech, Atlanta, United States of America
- 5 Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE - Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
- 6 Department of Computer Science, Johns Hopkins University, Baltimore, United States of America
- 7 Department of Haematology, University of Cambridge and NHS Blood and Transplant Cambridge Biomedical Campus, Cambridge, United Kingdom
- 8 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
- 9 Computational Biology, Ontario Institute for Cancer Research, Toronto, Canada
- 10 Cardiovascular Health Research Unit, University of Washington, Seattle, United States of America
- 11 Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
- 12 Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
- 13 Department of Public Health Sciences, University of Chicago, Chicago, United States of America
- 14 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
- 15 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
- 16 Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany
- 17 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
- 18 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
- 19 Exeter Medical School, University of Exeter, Exeter, United Kingdom
- 20 Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland
- 21 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
- 22 Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
- 23 Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland
- 24 Lausanne University Hospital, Lausanne, Switzerland
- 25 University of Helsinki, Helsinki, Finland
- 26 Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
- 27 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
- 28 Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
- 29 Leiden University Medical Center, Leiden, The Netherlands
- 30 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
- 31 Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liege, 1 Avenue de l’Hôpital, Liège 4000, Belgium
- 32 Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
- 33 Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
- 34 Department of Computer Science, Johns Hopkins University, Baltimore, United States of America
- 35 Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, United States of America
- 36 IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
- 37 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
- 38 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
- 39 Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan
- 40 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
- 41 Institute of Clinical Chemistry and Laboratory Medicine, Greifswald University Hospital, Greifswald, Germany
- 42 Faculty of Genes, Behavior and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
- 43 Stanford University, Stanford, United States of America
- 44 Turku University Hospital and University of Turku, Turku, Finland
- 45 Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
- 46 Department of Medicine, Universität Leipzig, Leipzig, Germany
- 47 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 48 Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
- 49 Institute for Laboratory Medicine, LIFE - Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
- 50 University Medical Center Utrecht, Utrecht, The Netherlands
- 51 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
- 52 Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
- 53 Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland
- 54 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
- 55 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany
- 56 Institute of Human Genetics, Technical University Munich, Munich, Germany.
- 57 Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States of America
- 58 Department of Medicine, University of Washington, Seattle, United States of America
- 59 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton Cambridge, United Kingdom
- 60 Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
- 61 Division of Computational Genomics and Systems Genetics, German Cancer Research Center, 69120 Heidelberg, Germany
- 62 Departments of Biomedical Engineering and Computer Science, Johns Hopkins University, Baltimore, United States of America
- 63 Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
- ↵# Correspondence can be addressed to Urmo VÕsa (urmo.vosa{at}gmail.com) Annique Claringbould (anniqueclaringbould{at}gmail.com) Lude Franke(ludefranke{at}gmail.com)