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DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Janine Arloth, View ORCID ProfileGökcen Eraslan, Till F.M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Müller-Myhsok, Marcella Rietschel, Fabian J. Theis, Elisabeth B. Binder, Nikola S. Mueller
doi: https://doi.org/10.1101/069096
Janine Arloth
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany
Gökcen Eraslan
2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany
Till F.M. Andlauer
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
3Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
Jade Martins
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
Stella Iurato
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
Brigitte Kühnel
5Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
16Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
Melanie Waldenberger
5Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
16Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
22German Centre for Cardiovascular Research (DZHK), 13316 Berlin, Germany
Josef Frank
6Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Ralf Gold
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
7Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44801 Bochum, Germany
Bernhard Hemmer
3Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
8Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany
Felix Luessi
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
9Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, 55122 Mainz, Germany
Sandra Nischwitz
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
Friedemann Paul
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
10NeuroCure Clinical Research Center, Department of Neurology, and Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, and Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany
Heinz Wiendl
4German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
11Department of Neurology with Institute of Translational Neurology, University of Münster, 48149 Münster, Germany
Christian Gieger
5Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
16Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
Stefanie Heilmann-Heimbach
12Institute of Human Genetics, University Hospital Bonn and Division of Genomics, Life & Brain Research Centre, University of Bonn School of Medicine, 53113 Bonn, Germany
Tim Kacprowski
13Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, 17489 Greifswald, Germany
21Junior Research Group on Computational Systems Medicine, Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany
Matthias Laudes
14Department I of Internal Medicine, Kiel University, 24105 Kiel, Germany
Thomas Meitinger
15Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany and Institute of Human Genetics, Technical University of Munich, 81675 Munich, Germany
Annette Peters
16Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
Rajesh Rawal
17Institute of Epidemiology and Social Medicine, University of Münster, 48149 Münster, Germany
Konstantin Strauch
18Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany and Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 80539 Munich, Germany
Susanne Lucae
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
Bertram Müller-Myhsok
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
8Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany
23Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Marcella Rietschel
6Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Fabian J. Theis
2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany
19Department of Mathematics, Technical University of Munich, Garching 85748, Germany
Elisabeth B. Binder
1Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
20Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA 30322, USA
Nikola S. Mueller
2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany
Article usage
Posted December 05, 2018.
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Janine Arloth, Gökcen Eraslan, Till F.M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Müller-Myhsok, Marcella Rietschel, Fabian J. Theis, Elisabeth B. Binder, Nikola S. Mueller
bioRxiv 069096; doi: https://doi.org/10.1101/069096
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Janine Arloth, Gökcen Eraslan, Till F.M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Müller-Myhsok, Marcella Rietschel, Fabian J. Theis, Elisabeth B. Binder, Nikola S. Mueller
bioRxiv 069096; doi: https://doi.org/10.1101/069096
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